JMV 7490 

JMV 7490 is a highly potent and highly hydrophilic neurotensin receptor NTS₁ probe that can be successfully labeled with ⁶⁸Ga and ¹¹¹In. JMV 7490 acts as an efflux inhibitor to reduce its efflux in NTS₁-positive cancer cells; it also serves as an internalization inducer and is efficiently and continuously internalized by NTS₁-positive cancer cells. ¹¹¹In-radiolabeled JMV 7490 shows persistent uptake in NTS₁-positive xenografts in nude mice, but no significant uptake in NTS₁-negative xenografts. JMV 7490 can be used for in vivo tracer applications of NTS1-positive tumors and supports related research on colorectal cancer^[1].

[⁶⁸Ga]Ga-JMV 7490 (0.1-500 nM; incubated at 4°C for 2 hours) binds to NTS₁ on HT-29 cells, with a K_d of 14.61 nM and an NTS1/NTS2 selectivity of 44.4; [¹¹¹In]In-JMV 7490 has a Kd of 77.47 nM against NTS1 and a selectivity of 6.5^[1].
[⁶⁸Ga]Ga-JMV 7490 exhibits complete ex vivo stability in human plasma, while [¹¹¹In]In-JMV 7490 retains only 76% and 61% of intact peptide after 2 h and 4 h of ex vivo incubation, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

[¹¹¹In]In-JMV 7490 (12 MBq/200 pmol; intravenous injection) shows extremely low uptake in NTS₁ -negative HEK 293T xenografts in male NMRI-Foxn1 nu/nu mice, whereas it effectively visualizes tumor sites in SPECT/CT imaging of HT-29 xenograft models ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1362.73

C₆₃H₁₁₁N₁₅O₁₆Si

{DOTA}-{β-Ala}-Lys-Lys-Lys-Pro-Tyr-Ile-{TMSAla}

{DOTA}-{β-Ala}-KKKPYI-{TMSAla}

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Bodin S, et al. N-Terminal Stabilization of Radiolabeled Neurotensin Analogues for Improved Tumor Uptake. J Med Chem. 2025;68(7):7280-7290.  [Content Brief]