1. GPCR/G Protein
    Neuronal Signaling
  2. Neurotensin Receptor
  3. SBI-553

SBI-553 

Cat. No.: HY-125880 Purity: 98.85%
Handling Instructions

SBI-553 is a potent and brain penetrant NTR1 allosteric modulator, with an EC50 of 0.34 μM.

For research use only. We do not sell to patients.

SBI-553 Chemical Structure

SBI-553 Chemical Structure

CAS No. : 1849603-72-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 347 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
25 mg USD 990 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
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Description

SBI-553 is a potent and brain penetrant NTR1 allosteric modulator, with an EC50 of 0.34 μM[1].

IC50 & Target

EC50: 0.34 μM (NTR1)[1].

Molecular Weight

450.55

Formula

C₂₆H₃₁FN₄O₂

CAS No.

1849603-72-0

SMILES

CN(C1=CC2=C(N=C(N=C2C=C1)C3(CC3)F)N4CCC(CC4)C5=C(C=CC=C5)OC)CCO

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (138.72 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2195 mL 11.0975 mL 22.1951 mL
5 mM 0.4439 mL 2.2195 mL 4.4390 mL
10 mM 0.2220 mL 1.1098 mL 2.2195 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.62 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.62 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

SBI-553SBI553SBI 553Neurotensin ReceptorInhibitorinhibitorinhibit

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Product name:
SBI-553
Cat. No.:
HY-125880
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