1849603-72-0
1849603-72-0
Chemical Structure
SBI-553
- CAS No.: 1849603-72-0
- Formula:C26H31FN4O2
- Molecular Weight:450.55
IUPAC Name: 2-((2-(1-fluorocyclopropyl)-4-(4-(2-methoxyphenyl)piperidin-1-yl)quinazolin-6-yl)(methyl)amino)ethan-1-ol
InChIKey: BLWXTJQMEBQCIZ-UHFFFAOYSA-N
SMILES: CN(C1=CC2=C(N=C(N=C2C=C1)C3(CC3)F)N4CCC(CC4)C5=C(C=CC=C5)OC)CCO
Biological Activity: SBI-553 is a potent and brain penetrant NTR1 allosteric modulator, with an EC50 of 0.34 μM[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SBI-553 | 99.73% | SBI-553 is a potent and brain penetrant NTR1 allosteric modulator, with an EC50 of 0.34 μM. | ||||||||||||||||||||
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References
- [1]. Pinkerton AB, et al. Discovery of β-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators. J Med Chem. 2019 Aug 20. [Content Brief]
- [2]. Slosky LM, et al. β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors. Cell. 2020 Jun 11;181(6):1364-1379.e14. [Content Brief]
Keywords
