1. GPCR/G Protein
    Neuronal Signaling
  2. Neurotensin Receptor
  3. ML314

ML314 

Cat. No.: HY-16639 Purity: 99.72%
Handling Instructions

ML314 is a potent molecule agonist of NTR1 (EC50 = 1.9 μM); showed good selectivity against NTR2 and GPR35, but did not stimulate Ca2+ mobilization.

For research use only. We do not sell to patients.

ML314 Chemical Structure

ML314 Chemical Structure

CAS No. : 1448895-09-7

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 158 In-stock
Estimated Time of Arrival: December 31
5 mg USD 144 In-stock
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10 mg USD 228 In-stock
Estimated Time of Arrival: December 31
25 mg USD 492 In-stock
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50 mg USD 840 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

ML314 is a potent molecule agonist of NTR1 (EC50 = 1.9 μM); showed good selectivity against NTR2 and GPR35, but did not stimulate Ca2+ mobilization. IC50 value: 1.9 uM (EC50) [1] Target: NTR1 agonist Medicinal chemistry optimization of MLS-0233108 led to ML314, the most potent molecule in this second series that exhibited full agonist behavior (100 %) on NTR1 (EC50 = 1.9 μM). ML314 showed good selectivity against NTR2 and GPR35, but did not stimulate Ca2+ mobilization. ML314 is potentially a biased agonist operating via the β-arrestin pathway rather than the traditional Gq coupled pathway. Signaling mediated by β-arrestin has distinct biochemical and functional consequences that may lead to physiological advantages as described below. This probe report describes the discovery and properties of ML301 and summarizes the HTS and follow-up campaign, which identified ML314.

Molecular Weight

420.50

Formula

C₂₄H₂₈N₄O₃

CAS No.

1448895-09-7

SMILES

COC1=CC=CC=C1N2CCN(C3=C4C=C(OC)C(OC)=CC4=NC(C5CC5)=N3)CC2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 47 mg/mL (111.77 mM)

*"≥" means soluble, but saturation unknown.

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Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3781 mL 11.8906 mL 23.7812 mL
5 mM 0.4756 mL 2.3781 mL 4.7562 mL
10 mM 0.2378 mL 1.1891 mL 2.3781 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

ML314ML 314ML-314Neurotensin ReceptorInhibitorinhibitorinhibit

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ML314
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HY-16639
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