1. GPCR/G Protein
    Neuronal Signaling
  2. Neurotensin Receptor
  3. Neurotensin

Neurotensin 

Cat. No.: HY-P0234 Purity: 97.32%
Handling Instructions

Neurotensin, a gut tridecapeptide, acts as a potent cellular mitogen for various colorectal and pancreatic cancers which possess high-affinity neurotensin receptors (NTR).

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Neurotensin Chemical Structure

Neurotensin Chemical Structure

CAS No. : 39379-15-2

Size Price Stock Quantity
1 mg USD 60 In-stock
Estimated Time of Arrival: December 31
5 mg USD 180 In-stock
Estimated Time of Arrival: December 31
10 mg USD 252 In-stock
Estimated Time of Arrival: December 31
25 mg USD 504 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Neurotensin, a gut tridecapeptide, acts as a potent cellular mitogen for various colorectal and pancreatic cancers which possess high-affinity neurotensin receptors (NTR).

IC50 & Target

Neurotensin receptors (NTR)[1]

In Vitro

Neurotensin induces the expression of MIP-2, MCP-1, IL-1β and TNFα in murine microglial cells and stimulates IL-8 secretion in a non-transformed colon epithelial cell line stably transfected with the NTR. The high-affinity NTR, a member of the G-protein coupled receptor (GPCR) family, is present in a majority of human pancreatic and colorectal cancers, suggesting that Neurotensin (NT) may act in an endocrine fashion to affect tumor growth. Acting through the NTR1, Neurotensin is known to stimulate various signal transduction pathways, including intracellular calcium ([Ca2+]i), the mitogen-activated protein kinases (MAPKs), ERK and JNK, and various PKC isoforms. Treatment of HCT116 cells with Neurotensin (100 nM) significantly increases HCT116 cell migration (~3-fold) compared with vehicle treatment; pretreatment with Curcumin (10 μM) blocksthe stimulatory effect of NT on HCT116 cell migration. ctivation of MEK/ERK by NT and downstream induction of AP-1 transcription factors contributes to the proliferative effects of Neurotensin[1].

Clinical Trial
Molecular Weight

1672.92

Formula

C₇₈H₁₂₁N₂₁O₂₀

CAS No.

39379-15-2

Sequence

Pyr-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu

Sequence Shortening

Pyr-LYENKPRRPYIL

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -80°C 2 years
  -20°C 1 year
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 33.33 mg/mL (19.92 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.5978 mL 2.9888 mL 5.9776 mL
5 mM 0.1196 mL 0.5978 mL 1.1955 mL
10 mM 0.0598 mL 0.2989 mL 0.5978 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

NeurotensinNeurotensin ReceptorInhibitorinhibitorinhibit

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Neurotensin
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