2. GPCR/G Protein Neuronal Signaling
  3. Neurotensin Receptor
  4. AF40431

AF40431, the first reported small-molecule ligand of sortilin, has an IC50 of 4.4 µM and a Kd of 0.7 µM . AF40431 is bound in the neurotensin-binding site of sortilin.

For research use only. We do not sell to patients.

AF40431 Chemical Structure

AF40431 Chemical Structure

CAS No. : 181125-92-8

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5 mg USD 290 In-stock
10 mg USD 465 In-stock
25 mg USD 930 In-stock
50 mg USD 1450 In-stock
100 mg USD 2050 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

AF40431, the first reported small-molecule ligand of sortilin, has an IC50 of 4.4 µM and a Kd of 0.7 µM . AF40431 is bound in the neurotensin-binding site of sortilin[1].

IC50 & Target

IC50: 4.4 µM (sortilin) Kd: 0.7 µM (sortilin)[1]
Molecular Weight

319.35

Formula

C17H21NO5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(C)C[C@@H](C(O)=O)NCC1=C(O2)C(C(C)=CC2=O)=CC=C1O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (78.28 mM; ultrasonic and adjust pH to 1 with TFA; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1314 mL 15.6568 mL 31.3136 mL
5 mM 0.6263 mL 3.1314 mL 6.2627 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1314 mL 15.6568 mL 31.3136 mL 78.2840 mL
5 mM 0.6263 mL 3.1314 mL 6.2627 mL 15.6568 mL
10 mM 0.3131 mL 1.5657 mL 3.1314 mL 7.8284 mL
15 mM 0.2088 mL 1.0438 mL 2.0876 mL 5.2189 mL
20 mM 0.1566 mL 0.7828 mL 1.5657 mL 3.9142 mL
25 mM 0.1253 mL 0.6263 mL 1.2525 mL 3.1314 mL
30 mM 0.1044 mL 0.5219 mL 1.0438 mL 2.6095 mL
40 mM 0.0783 mL 0.3914 mL 0.7828 mL 1.9571 mL
50 mM 0.0626 mL 0.3131 mL 0.6263 mL 1.5657 mL
60 mM 0.0522 mL 0.2609 mL 0.5219 mL 1.3047 mL
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AF40431 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AF40431181125-92-8AF 40431AF-40431Neurotensin ReceptorInhibitorinhibitorinhibit

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