AF40431
Based on 1 publication(s) in Google Scholar
AF40431, the first reported small-molecule ligand of sortilin, has an IC50 of 4.4 µM and a Kd of 0.7 µM . AF40431 is bound in the neurotensin-binding site of sortilin.
For research use only. We do not sell to patients.
- Purity: 98.09%
- CAS No.: 181125-92-8
- Formula: C17H21NO5
- Molecular Weight:319.35
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) AF40431
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Biological Activity
IC50: 4.4 µM (sortilin) Kd: 0.7 µM (sortilin)[1]
Chemical Information
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CAS No. 181125-92-8
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Appearance Solid
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Molecular Weight 319.35
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Formula C17H21NO5
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Color White to off-white
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SMILES
CC(C)C[C@@H](C(O)=O)NCC1=C(O2)C(C(C)=CC2=O)=CC=C1O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
DMSO : 25 mg/mL (78.28 mM; ultrasonic and adjust pH to 1 with TFA; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
1 M HCl : 3.33 mg/mL (10.43 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| 1 M HCl / DMSO | 1 mM | 3.1314 mL | 15.6568 mL | 31.3136 mL | 78.2840 mL |
| 5 mM | 0.6263 mL | 3.1314 mL | 6.2627 mL | 15.6568 mL | |
| 10 mM | 0.3131 mL | 1.5657 mL | 3.1314 mL | 7.8284 mL | |
| DMSO | 15 mM | 0.2088 mL | 1.0438 mL | 2.0876 mL | 5.2189 mL |
| 20 mM | 0.1566 mL | 0.7828 mL | 1.5657 mL | 3.9142 mL | |
| 25 mM | 0.1253 mL | 0.6263 mL | 1.2525 mL | 3.1314 mL | |
| 30 mM | 0.1044 mL | 0.5219 mL | 1.0438 mL | 2.6095 mL | |
| 40 mM | 0.0783 mL | 0.3914 mL | 0.7828 mL | 1.9571 mL | |
| 50 mM | 0.0626 mL | 0.3131 mL | 0.6263 mL | 1.5657 mL | |
| 60 mM | 0.0522 mL | 0.2609 mL | 0.5219 mL | 1.3047 mL |
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