1. GPCR/G Protein
    Neuronal Signaling
  2. Neurotensin Receptor
  3. AF40431

AF40431 

Cat. No.: HY-124673 Purity: 99.17%
Handling Instructions

AF40431, the first reported small-molecule ligand of sortilin, has an IC50 of 4.4 µM and a Kd of 0.7 µM . AF40431 is bound in the neurotensin-binding site of sortilin.

For research use only. We do not sell to patients.

AF40431 Chemical Structure

AF40431 Chemical Structure

CAS No. : 181125-92-8

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1  mL in DMSO USD 246 In-stock
Estimated Time of Arrival: December 31
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
25 mg USD 990 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

AF40431, the first reported small-molecule ligand of sortilin, has an IC50 of 4.4 µM and a Kd of 0.7 µM . AF40431 is bound in the neurotensin-binding site of sortilin[1].

IC50 & Target

IC50: 4.4 µM (sortilin) Kd: 0.7 µM (sortilin)[1]

Molecular Weight

319.35

Formula

C₁₇H₂₁NO₅

CAS No.

181125-92-8

SMILES

CC(C)C[[email protected]@H](C(O)=O)NCC1=C(O2)C(C(C)=CC2=O)=CC=C1O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (78.28 mM; ultrasonic and adjust pH to 1 with TFA)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1314 mL 15.6568 mL 31.3136 mL
5 mM 0.6263 mL 3.1314 mL 6.2627 mL
10 mM 0.3131 mL 1.5657 mL 3.1314 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

AF40431AF 40431AF-40431Neurotensin ReceptorInhibitorinhibitorinhibit

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AF40431
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HY-124673
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