2. GPCR/G Protein
    Neuronal Signaling
  3. Neurotensin Receptor
  4. AF38469

AF38469 

Cat. No.: HY-12802 Purity: 99.28%
COA Handling Instructions

AF38469 is a selective, orally bioavailable Sortilin inhibitor with an IC50 value of 330 nM.

For research use only. We do not sell to patients.

AF38469 Chemical Structure

AF38469 Chemical Structure

CAS No. : 1531634-31-7

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 308 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 308 In-stock
Solid
5 mg USD 280 In-stock
10 mg USD 450 In-stock
25 mg USD 900 In-stock
50 mg USD 1350 In-stock
100 mg USD 1980 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 8 publication(s) in Google Scholar

Top Publications Citing Use of Products

    AF38469 purchased from MCE. Usage Cited in: Am J Pathol. 2020 Sep;190(9):1931-1942.  [Abstract]

    Western blot detection of phosphorylation of FAK (Tyr925), FAK (Tyr397) and FAK (Tyr576/577) in the treatment with AF38469. The phosphorylation of residue Tyr925 of FAK is decreased in sortilin-inhibited compared to NT control.

    AF38469 purchased from MCE. Usage Cited in: Breast Cancer Res. 2018 Nov 20;20(1):137.   [Abstract]

    Immunohistochemical analyses of the GRN A- and AF38469-treated groups of MDA-MB 231 luc xenografts with skin is performed using Ki67 and haematoxylin staining.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    AF38469 is a selective, orally bioavailable Sortilin inhibitor with an IC50 value of 330 nM.

    IC50 & Target

    IC50:330 nM (Sortilin)[1]
    In Vivo

    AF38469 (1 mg/kg; i.v.) has a low volume of distribution (blood volume of 0.7 L/kg) and low clearance (4.8 L/h/kg), and a half-life (t1/2) of 1.2 h in rat[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    324.25

    Appearance

    Solid

    Formula

    C15H11F3N2O3
    CAS No.
    SMILES

    O=C(NC1=CC=CC(C)=N1)C2=CC=C(C(F)(F)F)C=C2C(O)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 43 mg/mL (132.61 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.0840 mL 15.4202 mL 30.8404 mL
    5 mM 0.6168 mL 3.0840 mL 6.1681 mL
    10 mM 0.3084 mL 1.5420 mL 3.0840 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  5% DMSO    40% PEG300    5% Tween-80    50% saline

      Solubility: 2.5 mg/mL (7.71 mM); Suspended solution; Need ultrasonic

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.08 mg/mL (6.41 mM); Clear solution

    *All of the co-solvents are available by MCE.
    Purity & Documentation

    Purity: 99.28%

    COA (252 KB) HNMR (164 KB) LCMS (404 KB)

    Handling Instructions (2659 KB)
    References
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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    AF384691531634-31-7AF 38469AF-38469Neurotensin ReceptorInhibitorinhibitorinhibit

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