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LM11A-31 dihydrochloride 

Cat. No.: HY-110155
Handling Instructions

LM11A-31 dihydrochloride, a p75NTR (neurotrophin receptor p75) Ligand, is a potent proNGF (nerve growth factor) antagonist. LM11A-31 dihydrochloride is a water-soluble, non-peptide with high blood-brain barrier permeability.

For research use only. We do not sell to patients.

LM11A-31 dihydrochloride Chemical Structure

LM11A-31 dihydrochloride Chemical Structure

CAS No. : 1243259-19-9

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Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in Water USD 55 In-stock
Estimated Time of Arrival: December 31
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 74 In-stock
Estimated Time of Arrival: December 31
25 mg USD 165 In-stock
Estimated Time of Arrival: December 31
50 mg USD 245 In-stock
Estimated Time of Arrival: December 31
100 mg USD 450 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

LM11A-31 dihydrochloride, a p75NTR (neurotrophin receptor p75) Ligand, is a potent proNGF (nerve growth factor) antagonist. LM11A-31 dihydrochloride is a water-soluble, non-peptide with high blood-brain barrier permeability[1][2].

IC50 & Target

proNGF[1]

In Vivo

LM11A-31 (oral gavage; 50 mg kg/day for 4 weeks) significantly mitigates proNGF accumulation and preserves BRB integrity[1].
LM11A-31 (orally; 50 or 75 mg/kg) administered for 3 months starting at 6-8 months of age prevents and/or reverses atrophy of basal forebrain cholinergic neurites and cortical dystrophic neurites in mid-stage male APPL/S mice[2].

Animal Model: Male C57BL/6 J mice[1]
Dosage: 50 mg kg/day
Administration: Oral gavage; for 4 weeks
Result: Mitigated proNGF accumulation and preserved BRB integrity.
Molecular Weight

316.27

Formula

C₁₂H₂₇Cl₂N₃O₂

CAS No.

1243259-19-9

SMILES

CC[[email protected]](C)[[email protected]](N)C(NCCN1CCOCC1)=O.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (395.23 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1619 mL 15.8093 mL 31.6186 mL
5 mM 0.6324 mL 3.1619 mL 6.3237 mL
10 mM 0.3162 mL 1.5809 mL 3.1619 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Product name:
LM11A-31 dihydrochloride
Cat. No.:
HY-110155
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