2. Neuronal Signaling Protein Tyrosine Kinase/RTK
  3. Trk Receptor
  4. Cyclotraxin B

Cyclotraxin B, a cyclic peptide, is a highly potent and selective TrkB inhibitor without altering the binding of BDNF. Cyclotraxin B non-competitively inhibits BDNF-induced TrkB activity with an IC50  of  0.30 nM. Cyclotraxin B can crosse the blood-brain-barrier and has analgesic and anxiolytic-like behavioral effects.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Cyclotraxin B Chemical Structure

Cyclotraxin B Chemical Structure

CAS No. : 1203586-72-4

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1 mg USD 170 In-stock
5 mg USD 360 In-stock
10 mg USD 590 In-stock
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Based on 3 publication(s) in Google Scholar

Other Forms of Cyclotraxin B:

Cyclotraxin B Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

Cyclotraxin B, a cyclic peptide, is a highly potent and selective TrkB inhibitor without altering the binding of BDNF. Cyclotraxin B non-competitively inhibits BDNF-induced TrkB activity with an IC50  of  0.30 nM. Cyclotraxin B can crosse the blood-brain-barrier and has analgesic and anxiolytic-like behavioral effects[1][2][3].

IC50 & Target

TrkB

 

Molecular Weight

1200.37

Formula

C48H73N13O17S3
CAS No.
Appearance

Solid

Color

White to off-white

Sequence Shortening

CNPMGYTKEGC (Disulfide bridge:Cys1-Cys11)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Stored under nitrogen, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (83.31 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8331 mL 4.1654 mL 8.3308 mL
5 mM 0.1666 mL 0.8331 mL 1.6662 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (83.31 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.8331 mL 4.1654 mL 8.3308 mL 20.8269 mL
5 mM 0.1666 mL 0.8331 mL 1.6662 mL 4.1654 mL
10 mM 0.0833 mL 0.4165 mL 0.8331 mL 2.0827 mL
15 mM 0.0555 mL 0.2777 mL 0.5554 mL 1.3885 mL
20 mM 0.0417 mL 0.2083 mL 0.4165 mL 1.0413 mL
25 mM 0.0333 mL 0.1666 mL 0.3332 mL 0.8331 mL
30 mM 0.0278 mL 0.1388 mL 0.2777 mL 0.6942 mL
40 mM 0.0208 mL 0.1041 mL 0.2083 mL 0.5207 mL
50 mM 0.0167 mL 0.0833 mL 0.1666 mL 0.4165 mL
60 mM 0.0139 mL 0.0694 mL 0.1388 mL 0.3471 mL
80 mM 0.0104 mL 0.0521 mL 0.1041 mL 0.2603 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Cyclotraxin B Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclotraxin B1203586-72-4Trk ReceptorTropomyosin related kinase receptorTrkBanxiolytic-likeBDNFcyclicpeptideBBBanalgesicInhibitorinhibitorinhibit

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