1203586-72-4
Chemical Structure
Cyclotraxin B
- CAS No.: 1203586-72-4
- Formula:C48H73N13O17S3
- Molecular Weight:1200.37
IUPAC Name: (3S,9S,12S,15S,18S,24R,29R,32S,37aS)-29-amino-32-(2-amino-2-oxoethyl)-15-(4-aminobutyl)-18-(2-carboxyethyl)-9-(4-hydroxybenzyl)-12-((R)-1-hydroxyethyl)-3-(2-(methylthio)ethyl)-1,4,7,10,13,16,19,22,30,33-decaoxotetratriacontahydro-1H-pyrrolo[2,1-b1][1,2]dithia[5,8,11,14,17,20,23,26,29,32]decaazacyclopentatriacontine-24-carboxylic acid
InChIKey: JLBMMJHZUYBFGX-ZHTCEXBHSA-N
SMILES: O=C1N2[C@](CCC2)([H])C(N[C@H](C(NCC(N[C@H](C(N[C@@](C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CSSC[C@@H](C(N[C@H]1CC(N)=O)=O)N)C(O)=O)=O)=O)CCC(O)=O)=O)CCCCN)=O)([H])[C@H](O)C)=O)CC3=CC=C(C=C3)O)=O)=O)CCSC)=O
Biological Activity: Cyclotraxin B is a BBB-penetrable and selective TrkB inhibitor. Cyclotraxin B inhibits BDNF-induced TrkB activity in a non-competitive manner, with an IC50 of 0.30 nM. Cyclotraxin B has analgesic and anxiolytic effects[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Cyclotraxin B | 99.78% | Cyclotraxin B is a BBB-penetrable and selective TrkB inhibitor. Cyclotraxin B inhibits BDNF-induced TrkB activity in a non-competitive manner, with an IC50 of 0.30 nM. Cyclotraxin B has analgesic and anxiolytic effects. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Maxime Cazorla, et al. Cyclotraxin-B, the first highly potent and selective TrkB inhibitor, has anxiolytic properties in mice. PLoS One. 2010 Mar 19;5(3):e9777. [Content Brief]
- [2]. Luis Constandil, et al. Cyclotraxin-B, a new TrkB antagonist, and glial blockade by propentofylline, equally prevent and reverse cold allodynia induced by BDNF or partial infraorbital nerve constriction in mice. J Pain. 2012 Jun;13(6):579-89. [Content Brief]
- [3]. Michel M M Verheij, et al. Systemic Delivery of a Brain-Penetrant TrkB Antagonist Reduces Cocaine Self-Administration and Normalizes TrkB Signaling in the Nucleus Accumbens and Prefrontal Cortex. J Neurosci. 2016 Aug 3;36(31):8149-59. [Content Brief]
