1. GPCR/G Protein
    Neuronal Signaling
  2. Neurotensin Receptor
  3. NTRC-824

NTRC-824 

Cat. No.: HY-12436 Purity: >98.0%
Handling Instructions

NTRC-824 (Compound 5) is a potent, selective and neurotensin-like nonpeptide neurotensin receptor type 2 (NTS2) antagonist with an IC50 of 38 nM and a Ki of 202 nM. NTRC-824 is >150-fold selectivity for NTS2 over NTS1 (Ki >30 μM).

For research use only. We do not sell to patients.

NTRC-824 Chemical Structure

NTRC-824 Chemical Structure

CAS No. : 1623002-61-8

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Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

NTRC-824 (Compound 5) is a potent, selective and neurotensin-like nonpeptide neurotensin receptor type 2 (NTS2) antagonist with an IC50 of 38 nM and a Ki of 202 nM. NTRC-824 is >150-fold selectivity for NTS2 over NTS1 (Ki >30 μM)[1].

IC50 & Target

IC50: 38 nM (Nurotensin receptor type 2)[1]
Ki: 202 nM (Nurotensin receptor type 2)[1]

In Vitro

Testing of NTRC-824 (Compound 5) at the NTS1 receptor shows no binding activity in the NTS1 assay up to 30 μM, making NTRC-824 (Compound 5) selective for NTS2 in both the binding and functional assays. NTRC-824 (Compound 5) is the first nonpeptide compound that behaves like, and is more active than, the endogenous ligand[1].

Molecular Weight

553.55

Formula

C₂₅H₂₆F₃N₃O₆S

CAS No.

1623002-61-8

SMILES

CC(C)C[[email protected]@H](C(O)=O)NC(CN1C=C(C(C(F)(F)F)=O)C2=C1C=CC(NS(=O)(C3=CC=C(C)C=C3)=O)=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >98.0%

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Keywords:

NTRC-824NTRC824NTRC 824Neurotensin ReceptorNTS2endogenousligandneurotensinanalgesicnonpeptidefunctionalInhibitorinhibitorinhibit

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NTRC-824
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HY-12436
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