6PPD
Based on 1 publication(s) in Google Scholar
6PPD is a rubber antioxidant that scavenges ozone and forms nitro radicals. Exposure to 6PPD reduces the hatching rate, impairs spontaneous locomotor activity, shortens body length and causes malformations in zebrafish embryos. 6PPD also induces oxidative stress in zebrafish embryos.
For research use only. We do not sell to patients.
- Purity: 98.46%
- CAS No.: 793-24-8
- Formula: C18H24N2
- Molecular Weight:268.40
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) 6PPD
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Customer Validation & Images
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Cell Imaging/Staining
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Cell Proliferation/Viability Assay
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WB
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Bio/Physico-chemical Assay
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Bio/Physico-chemical Assay
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:wild-type AB strain (2 hours post-fertilization embryos)[1]
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Dosage:0.0022 mg/L; 0.022 mg/L; 0.22 mg/L; 0.3125 mg/L; 0.625 mg/L; 1.25 mg/L; 2.5 mg/L; 5 mg/L
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Administration:aqueous exposure; daily renewal; 96 hours (0.3125-5 mg/L); 120 hours (0.0022-0.22 mg/L)
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Result:Determined the 96 h LC50 of 6PPD for zebrafish embryos as 2.2 mg/L .
Reduced hatchability by 25.6% (0.022 mg/L) and 78.9% (0.22 mg/L) relative to controls.
Reduced autonomous movement (60-second count at 96 hours) by 19.9% (0.022 mg/L) and 56.25% (0.22 mg/L) relative to controls.
Chemical Information
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CAS No. 793-24-8
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Appearance Solid
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Molecular Weight 268.40
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Formula C18H24N2
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Color Brown to gray
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SMILES
CC(C)CC(NC1=CC=C(NC2=CC=CC=C2)C=C1)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Ecotoxicol Environ Saf
2025 Dec 1:308:119496. PMID: 41330299
6PPD purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2025 Dec 1:308:119496. [Abstract]
6PPD (0.1-100 μM) exposure led to a concentration-dependent increase in dead cells, accompanied by a corresponding reduction in the live tissue area.
6PPD purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2025 Dec 1:308:119496. [Abstract]
The calculated IC50 of 6PPD was approximately 56.9 μM, with substantial cytotoxicity occurring only at concentrations above this threshold.
6PPD purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2025 Dec 1:308:119496. [Abstract]
Significant changes in apoptotic markers were observed only at 100 μM 6PPD.
6PPD purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2025 Dec 1:308:119496. [Abstract]
Acute electrophysiological responses were assessed by continuous MEA recording for 60 min following 6PPD treatment, with measurements taken at 10-min intervals.
6PPD purchased from MedChemExpress. Usage Cited in: Ecotoxicol Environ Saf. 2025 Dec 1:308:119496. [Abstract]
The beat rate (beats per minute, BPM) increased over 60 min at 10 μM 6PPD.
Solvent & Solubility
DMSO : 200 mg/mL (745.16 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : < 0.1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (597 KB)
- English - EN (597 KB)
- Français - FR (597 KB)
- Deutsch - DE (597 KB)
- Norwegian - NO (597 KB)
- Español - ES (597 KB)
- Swedish - SV (597 KB)
- Italian - IT (597 KB)
- Portuguese - PT (597 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7258 mL | 18.6289 mL | 37.2578 mL | 93.1446 mL |
| 5 mM | 0.7452 mL | 3.7258 mL | 7.4516 mL | 18.6289 mL | |
| 10 mM | 0.3726 mL | 1.8629 mL | 3.7258 mL | 9.3145 mL | |
| 15 mM | 0.2484 mL | 1.2419 mL | 2.4839 mL | 6.2096 mL | |
| 20 mM | 0.1863 mL | 0.9314 mL | 1.8629 mL | 4.6572 mL | |
| 25 mM | 0.1490 mL | 0.7452 mL | 1.4903 mL | 3.7258 mL | |
| 30 mM | 0.1242 mL | 0.6210 mL | 1.2419 mL | 3.1048 mL | |
| 40 mM | 0.0931 mL | 0.4657 mL | 0.9314 mL | 2.3286 mL | |
| 50 mM | 0.0745 mL | 0.3726 mL | 0.7452 mL | 1.8629 mL | |
| 60 mM | 0.0621 mL | 0.3105 mL | 0.6210 mL | 1.5524 mL | |
| 80 mM | 0.0466 mL | 0.2329 mL | 0.4657 mL | 1.1643 mL | |
| 100 mM | 0.0373 mL | 0.1863 mL | 0.3726 mL | 0.9314 mL |
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