1. GPCR/G Protein
  2. Neurotensin Receptor

Kinetensin (Synonyms: Kinetensin (human))

Cat. No.: HY-P1255
Handling Instructions

Kinetensin is a neurotensin-like peptide isolated from pepsin-treated human plasma.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Kinetensin Chemical Structure

Kinetensin Chemical Structure

CAS No. : 103131-69-7

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1 mg USD 90 Get quote
5 mg USD 180 Get quote
10 mg USD 290 Get quote

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References


Kinetensin is a neurotensin-like peptide isolated from pepsin-treated human plasma.

IC50 & Target

Neurotensin Receptor[1]

In Vitro

The peptide kinetensin isolated from pepsin-treated human plasma induces a dose-dependent release of histamine when exposed to rat peritoneal mast cells. The threshold concentration is around 1 μM, the ED50 is 10 μM, and the optimal concentration of between 100 to 1000 μM released 80% of the total histamine. Kinetensin is 10 to 100 times less potent than neurotensin and equipotent with the opioid peptide dynorphin. The histamine release is clearly temperature-dependent, with no release occurring at 0 or 45 °C and with an optimum around 37 °C. The histamine release is significantly reduced in the absence of extracellular calcium[2].

In Vivo

Kinetensin also induces a dose-dependent increase in vascular permeability when injected intradermally into rats[2].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8530 mL 4.2648 mL 8.5297 mL
5 mM 0.1706 mL 0.8530 mL 1.7059 mL
10 mM 0.0853 mL 0.4265 mL 0.8530 mL
*Please refer to the solubility information to select the appropriate solvent.
Cell Assay

Rat peritoneal mast cells are incubated with kinetensin at 37°C for 10 min. The incubation is stopped by the addition of 1.8 mL of ice-cold buffered saline and cells are separated from supernatant by centrifugation. Histamine release is expressed as per cent of total mast cell histamine[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration


Anesthetized Sprague-Dawley rats are given 25I-albumin i.v. Samples are then injected intradermally in 5x2 spots on the back and comprised saline as a control or kinetensin in different doses in 100 μL saline. After 20 rain, skin biopsies of 7 mm diameter are cut out, weighed and transferred to a gamma-counter. Results are expressed as: (counts per min (cpm) in tissue per gram wet weight/cpm in plasma per mL plasma)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight








Sequence Shortening



Please store the product under the recommended conditions in the Certificate of Analysis.


Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Cat. No.: HY-P1255