1. GPCR/G Protein
  2. Neurotensin Receptor
  3. Kinetensin

Kinetensin (Synonyms: Kinetensin (human))

Cat. No.: HY-P1255
Handling Instructions

Kinetensin is a neurotensin-like peptide isolated from pepsin-treated human plasma.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Kinetensin Chemical Structure

Kinetensin Chemical Structure

CAS No. : 103131-69-7

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  • Biological Activity

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Description

Kinetensin is a neurotensin-like peptide isolated from pepsin-treated human plasma.

IC50 & Target

Neurotensin Receptor[1]

In Vitro

The peptide kinetensin isolated from pepsin-treated human plasma induces a dose-dependent release of histamine when exposed to rat peritoneal mast cells. The threshold concentration is around 1 μM, the ED50 is 10 μM, and the optimal concentration of between 100 to 1000 μM released 80% of the total histamine. Kinetensin is 10 to 100 times less potent than neurotensin and equipotent with the opioid peptide dynorphin. The histamine release is clearly temperature-dependent, with no release occurring at 0 or 45 °C and with an optimum around 37 °C. The histamine release is significantly reduced in the absence of extracellular calcium[2].

In Vivo

Kinetensin also induces a dose-dependent increase in vascular permeability when injected intradermally into rats[2].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Cell Assay
[2]

Rat peritoneal mast cells are incubated with kinetensin at 37°C for 10 min. The incubation is stopped by the addition of 1.8 mL of ice-cold buffered saline and cells are separated from supernatant by centrifugation. Histamine release is expressed as per cent of total mast cell histamine[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
[2]

Rats[2]

Anesthetized Sprague-Dawley rats are given 25I-albumin i.v. Samples are then injected intradermally in 5x2 spots on the back and comprised saline as a control or kinetensin in different doses in 100 μL saline. After 20 rain, skin biopsies of 7 mm diameter are cut out, weighed and transferred to a gamma-counter. Results are expressed as: (counts per min (cpm) in tissue per gram wet weight/cpm in plasma per mL plasma)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

1172.38

Formula

C₅₆H₈₅N₁₇O₁₁

CAS No.

103131-69-7

Sequence

Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe-Leu

Sequence Shortening

IARRHPYFL

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Kinetensin
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Kinetensin

Cat. No.: HY-P1255