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Cat. No.: HY-134773

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Sigma-1 receptor modulator-1

Sigma-1 receptor modulator-1 is a sigma-1 receptor modulator and acetylcholinesterase (AChE) inhibitor. Sigma-1 receptor modulator-1 binds to sigma-1 receptors in guinea pigs with a K_i of 1.8 nM. Sigma-1 receptor modulator-1 modulates chaperone proteins, restores calcium homeostasis, and controls ROS production. Sigma-1 receptor modulator-1 inhibits AChE activity and scavenges free radicals. Sigma-1 receptor modulator-1 can be used for research on neurodegenerative diseases.

For research use only. We do not sell to patients.

CAS No.: 1688-45-5
Formula: C₁₄H₂₀ClNO₃
Molecular Weight:285.77

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Sigma-1 receptor modulator-1 Chemical Structure

CAS No.: 1688-45-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
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Biological Activity

Description

IC₅₀ & Target

^[1]

Sigma 1 Receptor

1.8 nM (Ki)

All Sigma Receptor Isoforms :

All Cholinesterase (ChE) Isoforms :

AChE
BChE

In Vitro

Sigma-1 receptor modulator-1 (compound 22) exhibits moderate AChE inhibitory activity in the spectrophotometric Ellman's assay (59.70% at 50 μM)^[1].
Sigma-1 receptor modulator-1 exhibits moderate affinity for S1R in guinea pig brain cortex and rat liver membranes, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1688-45-5
Molecular Weight 285.77
Formula C₁₄H₂₀ClNO₃
SMILES

O=C(CCN1CCOCC1)C2=CC=C(C=C2)OC.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Rui M, et al. Identification of dual Sigma1 receptor modulators/acetylcholinesterase inhibitors with antioxidant and neurotrophic properties, as neuroprotective agents. European journal of medicinal chemistry. 2018 Oct 05;158:353-370.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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