2. Anti-infection Metabolic Enzyme/Protease
  3. Bacterial Endogenous Metabolite
  4. Cecropin P1, porcine

Cecropin P1, porcine is an antibacterial peptide that can be isolated from the upper part of the small intestine of the pig. Cecropin P1, porcine shows antibacterial activity against Gram-negative bacteria. Cecropin P1, porcine shows antiviral activity and inhibits PRRSV infection.

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Cecropin P1, porcine Chemical Structure

Cecropin P1, porcine Chemical Structure

CAS No. : 125667-96-1

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10 mg USD 320 In-stock
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Based on 1 publication(s) in Google Scholar

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Cecropin P1, porcine Related Antibodies

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Description

Cecropin P1, porcine is an antibacterial peptide that can be isolated from the upper part of the small intestine of the pig. Cecropin P1, porcine shows antibacterial activity against Gram-negative bacteria. Cecropin P1, porcine shows antiviral activity and inhibits PRRSV infection[1][2].

In Vitro

Cecropin P1, porcine (0-480 μg/mL, 36-96 h) markedly inhibits CH-1a infection and replication in Marc-145 cells[2].
Cecropin P1, porcine (0-480 μg/mL, 36 h) not only displays extracellular virucidal activity against PRRSV (porcine reproductive and respiratory syndrome virus), but also exerts a potent inhibitory effect when added either before, simultaneously with, or after viral inoculation[2].
Cecropin P1, porcine (480 μg/mL, 0-72 h) blocks CH-1a-induced apoptosis during the late phase of infection[2].
Cecropin P1, porcine (0-480 μg/mL, 0-4 h) inhibits viral particle release[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cecropin P1, porcine Related Antibodies

Cell Viability Assay[2]

Cell Line: Marc-145 cells
Concentration: 160, 320, and 480 μg/mL
Incubation Time: 36, 48, 72, 96 h
Result: Significantly inhibited viral infection in a dose-dependent manner at 36 h postinfection. Inhibited CH-1a infection in Marc-145 cells with a 50% effective concentration (EC50) of 112 μg/mL. The 50% cytotoxic concentration (CC50) of Cecropin P1 for Marc-145 cells was estimated to be 719 μg/mL.

Western Blot Analysis[2]

Cell Line: Marc-145 cells
Concentration: 160, 320, and 480 μg/mL
Incubation Time: 36 h
Result: Significantly inhibited viral infection in a dose-dependent manner at 36 h postinfection. Significantly reduced the expression of the viral N protein when administered with either the pre-, co-, or posttreatment method.
In Vivo

Cecropin P1 (1 mg/kg, IP, once) prevents bacterial growth, endotoxemia, and mortality in rats with septic shock[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

3338.86

Formula

C147H253N45O43
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Ser-Trp-Leu-Ser-Lys-Thr-Ala-Lys-Lys-Leu-Glu-Asn-Ser-Ala-Lys-Lys-Arg-Ile-Ser-Glu-Gly-Ile-Ala-Ile-Ala-Ile-Gln-Gly-Gly-Pro-Arg
Sequence Shortening

SWLSKTAKKLENSAKKRISEGIAIAIQGGPR
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture and light, under nitrogen

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (14.98 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.2995 mL 1.4975 mL 2.9950 mL
5 mM 0.0599 mL 0.2995 mL 0.5990 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.87%

LCMS (264 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.2995 mL 1.4975 mL 2.9950 mL 7.4876 mL
5 mM 0.0599 mL 0.2995 mL 0.5990 mL 1.4975 mL
10 mM 0.0300 mL 0.1498 mL 0.2995 mL 0.7488 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Cecropin P1, porcine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cecropin P1, porcine125667-96-1BacterialEndogenous Metabolitebreast cancerMDA-MB-361BT-474NCI-N87SK-BR-3MDA-MB-453MDA-MB-175VIIHT115Calu-3fR2MRC-5anticancerorally activeInhibitorinhibitorinhibit

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