2. Anti-infection Metabolic Enzyme/Protease
  3. Bacterial Endogenous Metabolite
  4. Cecropin P1, porcine acetate

Cecropin P1, porcine acetate is an antibacterial peptide that can be isolated from the upper part of the small intestine of the pig. Cecropin P1, porcine acetate shows antibacterial activity against Gram-negative bacteria. Cecropin P1, porcine acetate shows antiviral activity and inhibits PRRSV infection.

For research use only. We do not sell to patients.

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Cecropin P1, porcine acetate Chemical Structure

Cecropin P1, porcine acetate Chemical Structure

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Cecropin P1, porcine acetate Related Antibodies

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Description

Cecropin P1, porcine acetate is an antibacterial peptide that can be isolated from the upper part of the small intestine of the pig. Cecropin P1, porcine acetate shows antibacterial activity against Gram-negative bacteria. Cecropin P1, porcine acetate shows antiviral activity and inhibits PRRSV infection[1][2].

In Vitro

Cecropin P1, porcine (0-480 μg/mL, 36-96 h) markedly inhibits CH-1a infection and replication in Marc-145 cells[2].
Cecropin P1, porcine (0-480 μg/mL, 36 h) not only displays extracellular virucidal activity against PRRSV (porcine reproductive and respiratory syndrome virus), but also exerts a potent inhibitory effect when added either before, simultaneously with, or after viral inoculation[2].
Cecropin P1, porcine (480 μg/mL, 0-72 h) blocks CH-1a-induced apoptosis during the late phase of infection[2].
Cecropin P1, porcine (0-480 μg/mL, 0-4 h) inhibits viral particle release[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cecropin P1, porcine acetate Related Antibodies

Cell Viability Assay[2]

Cell Line: Marc-145 cells
Concentration: 160, 320, and 480 μg/mL
Incubation Time: 36, 48, 72, 96 h
Result: Significantly inhibited viral infection in a dose-dependent manner at 36 h postinfection. Inhibited CH-1a infection in Marc-145 cells with a 50% effective concentration (EC50) of 112 μg/mL. The 50% cytotoxic concentration (CC50) of Cecropin P1 for Marc-145 cells was estimated to be 719 μg/mL.

Western Blot Analysis[2]

Cell Line: Marc-145 cells
Concentration: 160, 320, and 480 μg/mL
Incubation Time: 36 h
Result: Significantly reduced the expression of the viral N protein when administered with either the pre-, co-, or posttreatment method.
In Vivo

Cecropin P1 (1 mg/kg, IP, once) prevents bacterial growth, endotoxemia, and mortality in rats with septic shock[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

3398.91

Formula

C₁₄₉H₂₅₇N₄₅O₄₅
Sequence Shortening

SWLSKTAKKLENSAKKRISEGIAIAIQGGPR
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
Purity & Documentation
References
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Cecropin P1, porcine acetate Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cecropin P1, porcineBacterialEndogenous MetaboliteAntibacterial peptideMarc-145 cellsmacrophagesPRRSV infectionPorcine reproductive and respiratory syndromeantiviral activityCH-1a infectionseptic shockInhibitorinhibitorinhibit

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Cecropin P1, porcine acetate
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