GSK172981
GSK172981 is a brain-penetrant tachykinin NK3 receptor antagonist with pKi values of 7.7 and 7.8 for human and native guinea pig NK3 receptors, respectively. GSK172981 can be used for the study of schizophrenia.
For research use only. We do not sell to patients.
- CAS No.: 1133705-99-3
- Formula: C26H22FN3O
- Molecular Weight:411.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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hNK3 7.7 (pKi) |
Native guinea pig NK3 7.8 (pKi) |
In vitro functional evaluations revealed GSK172981 to be a competitive antagonist (pA2 = 7.2) at cloned human tachykinin NK3 receptor. GSK172981 also exhibits a competitive profile in antagonizing neurokinin B-stimulated neuronal activity recorded from the guinea pig medial habenula slices (apparent pKB = 8.1)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1133705-99-3
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Molecular Weight 411.47
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Formula C26H22FN3O
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SMILES
O=C(N[C@H](C1=CC=CC=C1)C2CC2)C3=C(C(C4=CC=CC(F)=C4)=NC5=CC=CC=C35)N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GSK172981 Related Classifications
HY-121164 Related Classifications
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