1. GPCR/G Protein
  2. Prostaglandin Receptor
  3. ONO 1301

ONO 1301 (Synonyms: ONO-AP 500-02)

Cat. No.: HY-106961
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ONO 1301 (ONO-AP 500-02), a prostaglandin (PG) I2 mimetic, is an orally active, long-acting prostacyclin agonist with thromboxane-synthase inhibitory activity. ONO 1301 promotes production of hepatocyte growth factor (HGF) from various cell types and ameliorates ischemia-induced left ventricle dysfunction in the mouse, rat and pig.

For research use only. We do not sell to patients.

ONO 1301 Chemical Structure

ONO 1301 Chemical Structure

CAS No. : 176391-41-6

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Description

ONO 1301 (ONO-AP 500-02), a prostaglandin (PG) I2 mimetic, is an orally active, long-acting prostacyclin agonist with thromboxane-synthase inhibitory activity. ONO 1301 promotes production of hepatocyte growth factor (HGF) from various cell types and ameliorates ischemia-induced left ventricle dysfunction in the mouse, rat and pig[1][2][3].

In Vitro

ONO 1301 (ONO-AP 500-02) inhibits collagen-induced aggregation in a concentration-dependent manner, with an IC50 value of 460 nM[3].
ONO-1301 (0-1000 nM) significantly increases alkaline phosphatase (ALP) activity in the primary osteoblasts and ST2 cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

ONO-1301 (6 mg/kg; p.o.; /daily for 4 weeks) improves the hemodynamic status of rats with dilated cardiomyopathy after experimental autoimmune myocarditis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight-week-old male Lewis rats (rat model of myosin-induced experimental autoimmune myocarditis)[1]
Dosage: 6 mg/kg
Administration: Orally; /daily for 4 weeks
Result: Hemodynamic parameters and plasma brain natriuretic peptide (BNP) level were significantly improved.
Molecular Weight

428.48

Formula

C26H24N2O4

CAS No.
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ONO 1301
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