2. Anti-infection
  3. Antibiotic Bacterial
  4. Valnemulin

Valnemulin is an orally active broad-spectrum antibiotic against Gram-negative and Gram-positive bacteria, anaerobic bacteria, Mycoplasma, and Spirochetes. Valnemulin ameliorates enteric diseases, acute polyarthritis and enzootic pneumonia in pigs. Valnemulin exhibits anti-inflammatory efficacy against lipopolysaccharide (HY-D1056)-induced lung injury.

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Valnemulin

Valnemulin Chemical Structure

CAS No. : 101312-92-9

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Based on 2 publication(s) in Google Scholar

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Valnemulin Related Antibodies

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Description

Valnemulin is an orally active broad-spectrum antibiotic against Gram-negative and Gram-positive bacteria, anaerobic bacteria, Mycoplasma, and Spirochetes. Valnemulin ameliorates enteric diseases, acute polyarthritis and enzootic pneumonia in pigs[1]. Valnemulin exhibits anti-inflammatory efficacy against lipopolysaccharide (HY-D1056)-induced lung injury[2].

Cellular Effect
Cell Line Type Value Description References
A549 CC50
46.21 μM
Compound: Valnemulin
Cytotoxicity against human A549 cells incubated for 24 hrs by CCK8 assay
Cytotoxicity against human A549 cells incubated for 24 hrs by CCK8 assay
[PMID: 37531743]
A549 CC50
88.01 μM
Compound: Valnemulin
Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 48 hrs by CCK8 assay
Cytotoxicity against human A549 cells assessed as reduction in cell viability measured after 48 hrs by CCK8 assay
[PMID: 37051724]
HEK293 CC50
31.1 μM
Compound: Valnemulin
Cytotoxicity against HEK293 cells incubated for 24 hrs by CCK8 assay
Cytotoxicity against HEK293 cells incubated for 24 hrs by CCK8 assay
[PMID: 37531743]
HEK293 CC50
65.44 μM
Compound: Valnemulin
Cytotoxicity against human HEK293 cells assessed as reduction in cell viability measured after 48 hrs by CCK8 assay
Cytotoxicity against human HEK293 cells assessed as reduction in cell viability measured after 48 hrs by CCK8 assay
[PMID: 37051724]
HepG2 CC50
37.26 μM
Compound: Valnemulin
Cytotoxicity against human HepG2 cells incubated for 24 hrs by CCK8 assay
Cytotoxicity against human HepG2 cells incubated for 24 hrs by CCK8 assay
[PMID: 37531743]
HepG2 CC50
87.31 μM
Compound: Valnemulin
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by CCK8 assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 48 hrs by CCK8 assay
[PMID: 37051724]
Vero IC50
14.9 μg/mL
Compound: Valnemulin
Cytotoxicity against African green monkey Vero cells after 72 hrs by MTT assay
Cytotoxicity against African green monkey Vero cells after 72 hrs by MTT assay
[PMID: 28291943]
Vero IC50
15 μg/mL
Compound: Valnemulin
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by MTT assay
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by MTT assay
[PMID: 30145051]
In Vitro

Valnemulin exhibits antimicrobial efficacy against Mycoplasma hyopneumoniae and Mycoplasma hyosynoviae, with MIC90s of 0.0005 μg/mL and 0.0001 to 0.00025 μg/mL, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Valnemulin Related Antibodies
In Vivo

Valnemulin (100 mg/kg, i.g., single dose) exhibits lung protectiv effects in LPS-induced acute lung injury in BALB/c mice[2].
Valnemulin hydrochloride (10 mg/kg, p.o.; 10 days) has a control effect in experimental infection of calves with Mycoplasma bovis, and can effectively eliminate Mycobacterium bovis in the lungs [3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Lipopolysaccharide induced acute lung injury in BALB/c mice[2].
Dosage: 100 mg/kg
Administration: i.g., single dose
Result: Reduced levels of neutrophils, lymphocytes and macrophages, and expressions of TNF-α, IL-6, and IL-1β in bronchoalveolar lavage fluid (BALF).
Increased superoxidase dismutase (SOD) activity in BALF, decreased myeloperoxidase (MAO) activity in lung.
Animal Model: Mycoplasma bovis infection treated male calves aged 10-35 days[3]
Dosage: 10 mg/kg
Administration: p.o., 10 days
Result: Resulted in a rapid diminution of clinical signs, restoration of appetite and reversal of weight loss.
Effectively reduced the isolation of Pasteurella multocida from the calves, lungs.
Molecular Weight

564.82

Formula

C31H52N2O5S
CAS No.
Appearance

Solid

SMILES

O=C(O[C@H]1[C@@]([C@H](C)CC2)(C)[C@@](C(CC3)=O)([H])[C@]32[C@@H](C)[C@H](O)[C@](C)(C=C)C1)CSC(C)(C)CNC([C@H](N)C(C)C)=O
Structure Classification
Initial Source

pig
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Valnemulin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Valnemulin101312-92-9AntibioticBacterialMycoplasma hyopneumoniaeMycoplasma hyosynoviaeBALB/c miceacute lung injuryInhibitorinhibitorinhibit

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