1. Immunology/Inflammation
  2. PGE synthase
  3. mPGES1-IN-3

mPGES1-IN-3 

Cat. No.: HY-100864
Handling Instructions

mPGES1-IN-3 (Compound 17d) is a potent and selective microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor, which exhibits excellent mPGES-1 enzyme (IC50: 8 nM), cell (A549 IC50: 16.24 nM) and human whole blood potency (IC50: 249.9 nM).

For research use only. We do not sell to patients.

mPGES1-IN-3 Chemical Structure

mPGES1-IN-3 Chemical Structure

CAS No. : 1469976-70-2

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Description

mPGES1-IN-3 (Compound 17d) is a potent and selective microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor, which exhibits excellent mPGES-1 enzyme (IC50: 8 nM), cell (A549 IC50: 16.24 nM) and human whole blood potency (IC50: 249.9 nM)[1].

IC50 & Target

IC50: 8 nM (mPGES-1)[1]

Molecular Weight

538.85

Formula

C₂₄H₁₆ClF₅N₄O₃

CAS No.

1469976-70-2

SMILES

O=C(NC1=CC(F)=CC(C(F)(F)F)=C1)C2=C(OCCO3)C3=C(N(C)C(NC4=C(Cl)C=CC=C4F)=N5)C5=C2

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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mPGES1-IN-3
Cat. No.:
HY-100864
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