2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor Trace Amine-associated Receptor (TAAR)
  4. Ractopamine

Ractopamine (LY031537 free base) is a potent and orally active β-adrenergic receptor (βAR) agonist with Kd value of ~25 nM for pig β1AR and β2AR. Ractopamine also is a mTAAR1 agonist with an EC50 of 16 μM. Ractopamine promotes muscle mass development, limits fat deposition, reduces feed consumption, increases total cellular protein synthesis, and improves growth rate and feed efficiency in finishing swine. Ractopamine can be used for researching to increase lean tissue growth and improve production efficiency in pigs.

For research use only. We do not sell to patients.

Ractopamine

Ractopamine Chemical Structure

CAS No. : 97825-25-7

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Ractopamine Related Antibodies

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Description

Ractopamine (LY031537 free base) is a potent and orally active β-adrenergic receptor (βAR) agonist with Kd value of ~25 nM for pig β1AR and β2AR. Ractopamine also is a mTAAR1 agonist with an EC50 of 16 μM. Ractopamine promotes muscle mass development, limits fat deposition, reduces feed consumption, increases total cellular protein synthesis, and improves growth rate and feed efficiency in finishing swine. Ractopamine can be used for researching to increase lean tissue growth and improve production efficiency in pigs[1][2][3][4][5].

IC50 & Target[5][1]

pig β1AR

~25 nM (Kd)

pig β2AR

~25 nM (Kd)

mTAAR1

16 μM (EC50)

Cellular Effect
Cell Line Type Value Description References
Sf9 IC50
0.33 μM
Compound: (rac)-3
Displacement of [3H]CGP1217 from human recombinant adrenergic beta2 receptor transfected in insect Sf9 cells by scintillation counting
Displacement of [3H]CGP1217 from human recombinant adrenergic beta2 receptor transfected in insect Sf9 cells by scintillation counting
[PMID: 19245211]
In Vitro

Ractopamine (50 nM-100 μM) acts as a full agonist of mouse trace amine-associated receptor 1 (mTAAR1) in Xenopus laevis oocytes coexpressing hCFTR and mTAAR1, with an EC50 of 16 μM, via a cAMP-dependent pathway[1].
Ractopamine increases protein accumulation and synthesis in postfusion ELC5 myotubes in a concentration-dependent manner[3].
Ractopamine shows Kd value of ~25 nM for pig β1AR and β2AR[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ractopamine Related Antibodies
In Vivo

Ractopamine (5-10 mg/kg; oral; divided into 3 daily portions; 28 days) supplementation in finishing pigs causes minimal changes to specific behaviors, no changes to stress-related cortisol or lactate levels or skin/carcass lesions, but doubles serum creatine kinase concentrations, indicating potential muscular effects[2].
Ractopamine (5-20 mg/kg; p.o.; daily; 48 days) administered in the diet of finishing swine linearly improves average daily gain, increases carcass weight and loin eye are[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: crossbred Camborough 25 × AGPIC 337 (170 barrows, 170 gilts, average initial body weight 107.3 kg)[2]
Dosage: 5 mg/kg; 10 mg/kg
Administration: oral; divided into 3 daily portions; 28 days
Result: Increased the average percentage of pigs nosing pen mates to 6.73% (vs control 5.62%) at 5 mg/kg.
Reduced the average percentage of pigs playing to 0.06% (vs control 0.26%) at 5 mg/kg.
Increased the average percentage of pigs drinking water to 2.06% (vs control 1.58%) at 5 mg/kg.
Increased the average percentage of pigs standing to 1.39% (vs control 0.85%) at 10 mg/kg.
Increased serum CK-MB concentration to 4361 U/L (vs control 2341 U/L) and serum CK-total concentration to 12,436 U/L (vs control 5811 U/L) at 5 mg/kg.
Increased serum CK-MB concentration to 4510 U/L (vs control 2341 U/L) and serum CK-total concentration to 10,707 U/L (vs control 5811 U/L) at 10 mg/kg.
Showed no significant effect on overall pig behavior classification, skin/carcass lesions, blood cortisol or lactate concentrations.
Molecular Weight

301.38

Formula

C18H23NO3
CAS No.
SMILES

OC(CNC(C)CCC1=CC=C(O)C=C1)C2=CC=C(O)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Ractopamine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ractopamine97825-25-7LY031537LY 031537LY-031537Adrenergic ReceptorTrace Amine-associated Receptor (TAAR)Beta Receptoradipose tissueβ1ARbeta-adrenergic agonisthCFTR chloride channelsGαs proteinβ2ARskeletal muscleintracellular cAMPfinishing swinemTAAR1Inhibitorinhibitorinhibit

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