97825-25-7
Chemical Structure
Ractopamine
Synonym(s): LY031537 free base
- CAS No.: 97825-25-7
- Formula:C18H23NO3
- Molecular Weight:301.38
IUPAC Name: 4-(1-hydroxy-2-((4-(4-hydroxyphenyl)butan-2-yl)amino)ethyl)phenol
InChIKey: YJQZYXCXBBCEAQ-UHFFFAOYSA-N
SMILES: OC(CNC(C)CCC1=CC=C(O)C=C1)C2=CC=C(O)C=C2
Biological Activity: Ractopamine (LY031537 free base) is a potent and orally active β-adrenergic receptor (βAR) agonist with Kd value of ~25 nM for pig β1AR and β2AR. Ractopamine also is a mTAAR1 agonist with an EC50 of 16 μM. Ractopamine promotes muscle mass development, limits fat deposition, reduces feed consumption, increases total cellular protein synthesis, and improves growth rate and feed efficiency in finishing swine. Ractopamine can be used for researching to increase lean tissue growth and improve production efficiency in pigs[1][2][3][4][5].
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Ractopamine | Ractopamine (LY031537 free base) is a potent and orally active β-adrenergic receptor (βAR) agonist with Kd value of ~25 nM for pig β1AR and β2AR. Ractopamine also is a mTAAR1 agonist with an EC50 of 16 μM. Ractopamine promotes muscle mass development, limits fat deposition, reduces feed consumption, increases total cellular protein synthesis, and improves growth rate and feed efficiency in finishing swine. Ractopamine can be used for researching to increase lean tissue growth and improve production efficiency in pigs. | |||||||||||||||||||||
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Ractopamine-d6 hydrochloride | Ractopamine-d6 (LY031537-d6) hydrochloride is the deuterium labeled Ractopamine hydrochloride (HY-B1421). Ractopamine (LY031537) hydrochloride is a potent β-adrenergic receptor (βAR) agonist with Kd values of ~25 nM for pig β1AR and β2AR. Ractopamine hydrochloride is linked to protein metabolism. Ractopamine hydrochloride can be used for researching to increase lean tissue growth and improve production efficiency in pigs. | |||||||||||||||||||||
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Ractopamine-d6 | Ractopamine-d6 is the deuterium labeled Ractopamine (HY-113781). Ractopamine (LY031537) hydrochloride is a potent β-adrenergic receptor (βAR) agonist with Kd values of ~25 nM for pig β1AR and β2AR. Ractopamine hydrochloride is linked to protein metabolism. Ractopamine hydrochloride can be used for researching to increase lean tissue growth and improve production efficiency in pigs. | |||||||||||||||||||||
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- [1]. Liu X, et al. Ractopamine, a livestock feed additive, is a full agonist at trace amine-associated receptor 1. J Pharmacol Exp Ther. 2014;350(1):124-129. [Content Brief]
- [2]. Athayde N B, et al. Stress susceptibility in pigs supplemented with ractopamine[J]. Journal of Animal Science, 2013, 91(9): 4180-4187. [Content Brief]
- [3]. Anderson P T, et al. Ractopamine increases total and myofibrillar protein synthesis in cultured rat myotubes[J]. The Journal of nutrition, 1990, 120(12): 1677-1683. [Content Brief]
- [4]. Stites CR, et al. The effect of ractopamine hydrochloride on the carcass cutting yields of finishing swine. J Anim Sci. 1991;69(8):3094-3101. [Content Brief]
- [5]. Mills S E. Biological basis of the ractopamine response[J]. Journal of Animal Science, 2002, 80(E-suppl_2): E28-E32.
