NPC-14695
NPC-14695 is a competitive and selective M3 muscarinic receptor antagonist, with a Kd value of 15 nM for guinea pig M3, 60 nM for guinea pig M2, and 25 nM for rabbit M1. NPC-14695 exhibits higher activity towards M3 receptors in bronchial smooth muscle than towards those regulating salivary secretion. NPC-14695 inhibits Carbachol (HY-B1208)-induced contraction of isolated rabbit iris smooth muscle.
For research use only. We do not sell to patients.
- CAS No.: 146561-59-3
- Formula: C24H30N2O2
- Molecular Weight:378.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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mAChR3 15 nM (Kd) |
mAChR2 60 nM (Kd) |
mAChR1 25 nM (Kd) |
NPC-14695 (1 nM-10 μM) inhibits carbachol (HY-B1208)-induced contraction of isolated rabbit iris smooth muscle[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 146561-59-3
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Molecular Weight 378.51
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Formula C24H30N2O2
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SMILES
O=C(C(C1=CC=CC=C1)(C2CCC2)O)CN3CCN(CC3)CC4=CC=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NPC-14695 Related Classifications
HY-183932 Related Classifications
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