2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. NPC-14695

NPC-14695 is a competitive and selective M3 muscarinic receptor antagonist, with a Kd value of 15 nM for guinea pig M3, 60 nM for guinea pig M2, and 25 nM for rabbit M1. NPC-14695 exhibits higher activity towards M3 receptors in bronchial smooth muscle than towards those regulating salivary secretion. NPC-14695 inhibits Carbachol (HY-B1208)-induced contraction of isolated rabbit iris smooth muscle.

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NPC-14695

NPC-14695 Chemical Structure

CAS No. : 146561-59-3

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NPC-14695 Related Antibodies

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Description

NPC-14695 is a competitive and selective M3 muscarinic receptor antagonist, with a Kd value of 15 nM for guinea pig M3, 60 nM for guinea pig M2, and 25 nM for rabbit M1. NPC-14695 exhibits higher activity towards M3 receptors in bronchial smooth muscle than towards those regulating salivary secretion. NPC-14695 inhibits Carbachol (HY-B1208)-induced contraction of isolated rabbit iris smooth muscle[1][2].

IC50 & Target[1]

mAChR3

15 nM (Kd)

mAChR2

60 nM (Kd)

mAChR1

25 nM (Kd)

In Vitro

NPC-14695 (10-9-10-6 M) inhibits carbachol (HY-B1208)-induced contraction of isolated rabbit iris smooth muscle[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NPC-14695 Related Antibodies
Molecular Weight

378.51

Formula

C24H30N2O2
CAS No.
SMILES

O=C(C(C1=CC=CC=C1)(C2CCC2)O)CN3CCN(CC3)CC4=CC=CC=C4
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NPC-14695 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NPC-14695146561-59-3NPC14695NPC 14695mAChRMuscarinic acetylcholine receptorcarbachol-induced contractionssalivary secretionmuscarinic receptor antagonistguinea pig M3bronchial smooth muscle M3 receptorsM3 muscarinic receptorsrabbit M1isolated rabbit iris smooth muscleguinea pig M2Inhibitorinhibitorinhibit

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