146561-59-3
146561-59-3
Chemical Structure
NPC-14695
- CAS 番号: 146561-59-3
- Formula:C24H30N2O2
- Molecular Weight:378.51
InChIKey: YTZUOZVKZMXBOP-UHFFFAOYSA-N
SMILES: O=C(C(C1=CC=CC=C1)(C2CCC2)O)CN3CCN(CC3)CC4=CC=CC=C4
Biological Activity: NPC-14695 is a competitive and selective M3 muscarinic receptor antagonist, with a Kd value of 15 nM for guinea pig M3, 60 nM for guinea pig M2, and 25 nM for rabbit M1. NPC-14695 exhibits higher activity towards M3 receptors in bronchial smooth muscle than towards those regulating salivary secretion. NPC-14695 inhibits Carbachol (HY-B1208)-induced contraction of isolated rabbit iris smooth muscle[1][2].
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NPC-14695 | NPC-14695 is a competitive and selective M3 muscarinic receptor antagonist, with a Kd value of 15 nM for guinea pig M3, 60 nM for guinea pig M2, and 25 nM for rabbit M1. NPC-14695 exhibits higher activity towards M3 receptors in bronchial smooth muscle than towards those regulating salivary secretion. NPC-14695 inhibits Carbachol (HY-B1208)-induced contraction of isolated rabbit iris smooth muscle. | |||||||||||||||||||||
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References
- [1]. Cardelús I, et al. Anticholinergic effects of desloratadine, the major metabolite of loratadine, in rabbit and guinea-pig iris smooth muscle. Eur J Pharmacol. 1999;374(2):249-254. [Content Brief]
- [2]. Broadley K J, et al. Muscarinic receptor agonists and antagonists[J]. Molecules, 2001, 6(3): 142-193.
