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  4. Y 9000

Y 9000 is an orally active antiallergic and anti-inflammatory compound. Y 9000 targets mast cells, inhibits the release of allergic mediators, stimulates the adrenal glands, exhibits glucocorticoid-like activity, and reduces adrenal ascorbic acid content. Y 9000 inhibits IgE-mediated and IgG-mediated allergic reactions as well as active systemic anaphylaxis in mice. Y 9000 inhibits allergic wheezing in passively sensitized guinea pigs and protects against active systemic anaphylactic shock in mice. Y 9000 inhibits non-immune responses in rats, including dextran-induced histamine release, anaphylactoid reactions and paw swelling. Y 9000 can be used in the research of allergic diseases (asthma, allergic rhinitis, urticaria, etc.).

For research use only. We do not sell to patients.

Y 9000

Y 9000 Chemical Structure

CAS No. : 53944-40-4

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Description

Y 9000 is an orally active antiallergic and anti-inflammatory compound. Y 9000 targets mast cells, inhibits the release of allergic mediators, stimulates the adrenal glands, exhibits glucocorticoid-like activity, and reduces adrenal ascorbic acid content. Y 9000 inhibits IgE-mediated and IgG-mediated allergic reactions as well as active systemic anaphylaxis in mice. Y 9000 inhibits allergic wheezing in passively sensitized guinea pigs and protects against active systemic anaphylactic shock in mice. Y 9000 inhibits non-immune responses in rats, including dextran-induced histamine release, anaphylactoid reactions and paw swelling. Y 9000 can be used in the research of allergic diseases (asthma, allergic rhinitis, urticaria, etc.)[1].

In Vivo

Y 9000 (5-50 mg/kg; p.o.; single dose 1 hour pre-antigen; 0.5-50 mg/kg; i.p.; single dose 30 minutes pre-antigen) inhibits IgE-mediated 48-hour homologous PCA in rats in a dose-dependent manner, with an oral ED50 of 11 mg/kg for egg albumin-induced PCA and intraperitoneal ED50 of 2.7 mg/kg[1].
Y 9000 (50-250 mg/kg; p.o.; single dose 1 hour pre-antigen; 5-100 mg/kg; i.p.; single dose 30 minutes pre-antigen; 25-100 mg/kg; p.o.; single dose 1 hour pre-antigen in adrenalectomized rats) inhibits IgG-mediated 4-hour heterologous PCA in intact rats in a dose-dependent manner, with an oral ED50 of 75 mg/kg and intraperitoneal ED50 of 14 mg/kg, and this inhibitory effect is reduced in adrenalectomized rats[1].
Y 9000 (5-25 mg/kg; i.p.; single dose 30 minutes pre-antigen; 100 mg/kg; p.o.; single dose 2 hours pre-antigen) inhibits IgE-mediated active anaphylactic bronchoconstriction in sensitized rats in a dose-dependent manner via intraperitoneal and oral routes[1].
Y 9000 (25-100 mg/kg; i.p.; single dose 30 minutes pre-aerosol challenge) inhibits IgG-mediated anaphylactic asthma in passively sensitized guinea pigs via intraperitoneal administration, with an ED50 of 50 mg/kg[1].
Y 9000 (100-500 mg/kg; p.o.; single dose 1 hour pre-antigen; 10-100 mg/kg; i.p.; single dose 30 minutes pre-antigen) dose-dependently protects against active systemic anaphylaxis in sensitized mice, with an oral ED50 of ~250 mg/kg and intraperitoneal ED50 of 50 mg/kg[1].
Y 9000 (2.5-25 mg/kg; p.o.; single dose 1 hour pre-induction; 0.5-10 mg/kg; i.p.; single dose 30 minutes pre-induction) inhibits egg albumin-induced anaphylactoid reactions in rats in a dose-dependent manner via oral and intraperitoneal routes, with an oral ED50 of 4 mg/kg and intraperitoneal ED50 of 1 mg/kg[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar rats (male, 180g body weight; male, 200g body weight; allergic reaction model via 48-hour homologous passive cutaneous anaphylaxis induced by anti-egg albumin rat serum or anti-dinitrophenol-ascaris rat serum)[1]
Dosage: 5-50 mg/kg (p.o.); 0.5-50 mg/kg (i.p.)
Administration: p.o.; single dose 1 hour pre-antigen; i.p.; single dose 30 minutes pre-antigen
Result: Suppressed egg albumin-triggered PCA dose-dependently via oral and intraperitoneal routes, with oral ED50 of 11 mg/kg and intraperitoneal ED50 of 2.7 mg/kg.
Suppressed DNP-As-induced PCA orally in a serum dilution-dependent fashion, with ED50 values of 30 mg/kg (1:30), 11 mg/kg (1:50) and ~4 mg/kg (1:100).
Animal Model: Wistar rats (male, 180g body weight; adrenalectomized male, 180g body weight, 5 days post-surgery; allergic reaction model via 4-hour heterologous passive cutaneous anaphylaxis induced by anti-egg albumin rabbit serum)[1]
Dosage: 50-250 mg/kg (p.o. intact rats); 5-100 mg/kg (i.p. intact rats); 25-100 mg/kg (p.o. adrenalectomized rats)
Administration: p.o.; single dose 1 hour pre-antigen; i.p.; single dose 30 minutes pre-antigen
Result: Suppressed IgG-dependent 4 hr heterologous PCA in normal rats dose-dependently, with oral ED50 = 75 mg/kg and intraperitoneal ED50 = 14 mg/kg.
Suppressed IgG-dependent 4 hr heterologous PCA by 26% and 61% at oral 25 mg/kg and 100 mg/kg in adrenalectomized rats.
Animal Model: Wistar rats (female, 200g body weight; allergic asthma model via active anaphylactic bronchoconstriction induced by egg albumin and Bordetella pertussis vaccine sensitization)[1]
Dosage: 5-25 mg/kg (i.p.); 100 mg/kg (p.o.)
Administration: i.p.; single dose 30 minutes pre-antigen; p.o.; single dose 2 hours pre-antigen
Result: Suppressed antigen-triggered anaphylactic bronchoconstriction dose-dependently via intraperitoneal injection and matched the potency of disodium cromoglycate; oral 100 mg/kg also exerted prominent suppressive effects.
Animal Model: Guinea pigs (male, 300-400g body weight; allergic asthma model via anaphylactic asthma induced by passive sensitization with anti-egg albumin rabbit serum and egg albumin aerosol challenge)[1]
Dosage: 25-100 mg/kg
Administration: i.p.; single dose 30 minutes pre-aerosol challenge
Result: Protected 0/10, 5/10, 6/10 animals from anaphylactic asthma at intraperitoneal doses of 25 mg/kg, 50 mg/kg, 100 mg/kg respectively, with an ED50 of 50 mg/kg.
Animal Model: ICR mice (female, 20-25g body weight; allergic reaction model via active systemic anaphylaxis induced by egg albumin and Bordetella pertussis vaccine sensitization)[1]
Dosage: 100-500 mg/kg (p.o.); 10-100 mg/kg (i.p.)
Administration: p.o.; single dose 1 hour pre-antigen; i.p.; single dose 30 minutes pre-antigen
Result: Suppressed lethal active systemic anaphylaxis dose-dependently.
Animal Model: Wistar rats (male, 180-200g body weight; anaphylactoid reaction model via egg albumin-induced anaphylactoid reaction)[1]
Dosage: 2.5-25 mg/kg (p.o.); 0.5-10 mg/kg (i.p.)
Administration: p.o.; single dose 1 hour pre-induction; i.p.; single dose 30 minutes pre-induction
Result: Suppressed egg albumin-evoked anaphylactoid responses dose-dependently, with oral ED50 of 4 mg/kg and intraperitoneal ED50 of 1 mg/kg; intraperitoneal potency was approximately 3.4-fold higher than disodium cromoglycate.
Molecular Weight

239.23

Formula

C14H9NO3
CAS No.
SMILES

O=C1C2=CC(C(C)=O)=CC=C2OC3=NC=CC=C31
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Y 900053944-40-4Y9000Y-9000Biochemical Assay ReagentsIgG-mediated reactionsdextran-induced histamine releaseIgE-mediated reactionsglucocorticoid-like activityallergic diseasespaw edemamouse active systemic anaphylactic reactionsanaphylactoid reactionallergic mediatorsadrenalsInhibitorinhibitorinhibit

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