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    Antibiotic
  3. Tylosin phosphate

Tylosin phosphate 

Cat. No.: HY-B0519B
Handling Instructions

Tylosin phosphate is a macrolide antibiotic found naturally as a fermentation product of Streptomyces fradiae. Tylosin tartrate exerts potent antimicrobial activity against Gram-positive bacteria. Tylosin phosphate is widely used as a feed additive for promoting animal growth. Tylosin phosphate is used for veterinary purposes against bacterial dysentery and respiratory diseases in poultry, pigs and cattle.

For research use only. We do not sell to patients.

Tylosin phosphate Chemical Structure

Tylosin phosphate Chemical Structure

CAS No. : 1405-53-4

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Solution
10 mM * 1 mL in DMSO USD 79 Ask For Quote & Lead Time
Solid
50 mg USD 72 Ask For Quote & Lead Time

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Description

Tylosin phosphate is a macrolide antibiotic found naturally as a fermentation product of Streptomyces fradiae. Tylosin tartrate exerts potent antimicrobial activity against Gram-positive bacteria. Tylosin phosphate is widely used as a feed additive for promoting animal growth. Tylosin phosphate is used for veterinary purposes against bacterial dysentery and respiratory diseases in poultry, pigs and cattle[1][2][3].

IC50 & Target

Antibiotic[1]

In Vitro

Tylosin phosphate exerts antibacterial effects by binding to 23S rRNA of the bacterial ribosomal 50S subunit [1].
Tylosin phosphate also prevents growth of Gram-negative strains, with MICs of 64 μg/mL, 32 μg/mL, 512 μg/mL and 1 μg/mL for M. haemolytica 11935, P. multocida 4407, E. coli ATCC 25922 and E. coli AS19rlmAI, respectively[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Tylosin phosphate (10-500 mg/kg; s.c.) generally suppresses the elevated TNF-α and IL-1β levels and increases the IL-10 levels in the Lipopolysaccharide (LPS) -treated animals[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/C mice (2-3 months old, 20-25 g)[4]
Dosage: 10 mg/kg, 100 mg/kg, 500 mg/kg
Administration: Subcutaneous injection
Result: Reduced the elevated TNF-α and IL-1β in LPS (250 µg)-treated mice but increased their IL-10 levels.
Molecular Weight

1014.10

Formula

C₄₆H₈₀NO₂₁P

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Tylosin phosphate
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HY-B0519B
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