1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Tylosin

Tylosin (Synonyms: Tylosin A)

Cat. No.: HY-B0519A Purity: ≥98.0%
Handling Instructions

Tylosin (Tylosin A) is a macrolide antibiotic found naturally as a fermentation product of Streptomyces fradiae. Tylosin exerts potent antimicrobial activity against Gram-positive bacteria. Tylosin is widely used as a feed additive for promoting animal growth. Tylosin is used for veterinary purposes against bacterial dysentery and respiratory diseases in poultry, pigs and cattle.

For research use only. We do not sell to patients.

Tylosin Chemical Structure

Tylosin Chemical Structure

CAS No. : 1401-69-0

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 79 In-stock
Estimated Time of Arrival: December 31
Solid
50 mg USD 72 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
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Based on 1 publication(s) in Google Scholar

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Description

Tylosin (Tylosin A) is a macrolide antibiotic found naturally as a fermentation product of Streptomyces fradiae. Tylosin exerts potent antimicrobial activity against Gram-positive bacteria. Tylosin is widely used as a feed additive for promoting animal growth. Tylosin is used for veterinary purposes against bacterial dysentery and respiratory diseases in poultry, pigs and cattle[1][2][3].

IC50 & Target

Antibiotic[1]

In Vitro

Tylosin exerts antibacterial effects by binding to 23S rRNA of the bacterial ribosomal 50S subunit [1].
Tylosin also prevents growth of Gram-negative strains, with MICs of 64 μg/mL, 32 μg/mL, 512 μg/mL and 1 μg/mL for M. haemolytica 11935, P. multocida 4407, E. coli ATCC 25922 and E. coli AS19rlmAI, respectively[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Tylosin (10-500 mg/kg; s.c.) generally suppresses the elevated TNF-α and IL-1β levels and increases the IL-10 levels in the Lipopolysaccharide (LPS) -treated animals[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/C mice (2-3 months old, 20-25 g)[4]
Dosage: 10 mg/kg, 100 mg/kg, 500 mg/kg
Administration: Subcutaneous injection
Result: Reduced the elevated TNF-α and IL-1β in LPS (250 µg)-treated mice but increased their IL-10 levels.
Molecular Weight

916.10

Formula

C₄₆H₇₇NO₁₇

CAS No.
SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (109.16 mM)

H2O : 0.67 mg/mL (0.73 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0916 mL 5.4579 mL 10.9158 mL
5 mM 0.2183 mL 1.0916 mL 2.1832 mL
10 mM 0.1092 mL 0.5458 mL 1.0916 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (2.73 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (2.73 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.73 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: ≥98.0%

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Keywords:

TylosinTylosin ABacterialAntibioticantibioticveterinarybacterialdysenteryrespiratorydiseasesatrophicrhinitismastitismycoplasmainfectionspoultryInhibitorinhibitorinhibit

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Tylosin
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HY-B0519A
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