2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. RS 39604

RS 39604 is a potent, selective, and orally active 5-HT4 receptor antagonist with a pKi of 9.1 in guinea pig striatal membranes. RS 39604 displays a low affinity (pKi<6.5) for 5-HT1A, 5-HT2C, 5-HT3, α1c, D1, D2, M1, M2, AT1, B1 and opioid mu receptors and moderate affinity for δ1, (pKi=6.8) and δ2 (pKi=7.8) sites.

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RS 39604 Chemical Structure

RS 39604 Chemical Structure

CAS No. : 167710-87-4

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Based on 1 publication(s) in Google Scholar

RS 39604 Related Antibodies

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5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

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Description

RS 39604 is a potent, selective, and orally active 5-HT4 receptor antagonist with a pKi of 9.1 in guinea pig striatal membranes. RS 39604 displays a low affinity (pKi<6.5) for 5-HT1A, 5-HT2C, 5-HT3, α1c, D1, D2, M1, M2, AT1, B1 and opioid mu receptors and moderate affinity for δ1, (pKi=6.8) and δ2 (pKi=7.8) sites[1].

IC50 & Target[1]

5-HT4 Receptor

9.1 (pKi)

Molecular Weight

590.56

Formula

C26H37Cl2N3O6S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CS(=O)(NCCN1CCC(CCC(C2=CC(Cl)=C(N)C=C2OCC3=CC(OC)=CC(OC)=C3)=O)CC1)=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: ≥98.0%

COA (250 KB)

Handling Instructions (2659 KB)
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RS 39604 Related Classifications

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RS 39604167710-87-4RS39604RS-396045-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptorselectiveorally activelong-lastingvisceral paincolorectal distensionInhibitorinhibitorinhibit

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