2. Cell Cycle/DNA Damage Epigenetics
  3. Sirtuin
  4. D-Galacto-D-mannan

D-Galacto-D-mannan  (Synonyms: Carob galactomannan)

Cat. No.: HY-W145481A
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D-Galacto-D-mannan (Carob galactomannan) is an orally active Dectin-2 agonist. D-Galacto-D-mannan exerts antioxidant activity against hydroxyl radical generation. D-Galacto-D-mannan activates Dectin-2 to trigger downstream signaling pathways, promote the expression of immunoregulatory molecules, coordinate innate and adaptive immune responses, and inhibit excessive inflammatory responses by upregulating the expression of Sirtuin 1. When used as a vaccine adjuvant, D-Galacto-D-mannan induces cellular and humoral immune responses, promotes IFNγ secretion, increases antibody levels and virus neutralization titers, and elevates the levels of immunoglobulin G and A. D-Galacto-D-mannan can serve as an adjuvant for foot-and-mouth disease vaccines, enhance the vaccine-mediated ability of hosts to defend against viral infection in mice, and reduce local side effects at the inoculation site in pigs. D-Galacto-D-mannan can be used in the research of inflammatory and immune diseases, such as foot-and-mouth disease.

For research use only. We do not sell to patients.

D-Galacto-D-mannan

D-Galacto-D-mannan Chemical Structure

CAS No. : 11078-30-1

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Based on 1 publication(s) in Google Scholar

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D-Galacto-D-mannan Related Antibodies

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Description

D-Galacto-D-mannan (Carob galactomannan) is an orally active Dectin-2 agonist. D-Galacto-D-mannan exerts antioxidant activity against hydroxyl radical generation. D-Galacto-D-mannan activates Dectin-2 to trigger downstream signaling pathways, promote the expression of immunoregulatory molecules, coordinate innate and adaptive immune responses, and inhibit excessive inflammatory responses by upregulating the expression of Sirtuin 1. When used as a vaccine adjuvant, D-Galacto-D-mannan induces cellular and humoral immune responses, promotes IFNγ secretion, increases antibody levels and virus neutralization titers, and elevates the levels of immunoglobulin G and A. D-Galacto-D-mannan can serve as an adjuvant for foot-and-mouth disease vaccines, enhance the vaccine-mediated ability of hosts to defend against viral infection in mice, and reduce local side effects at the inoculation site in pigs. D-Galacto-D-mannan can be used in the research of inflammatory and immune diseases, such as foot-and-mouth disease[1].

In Vitro

D-Galacto-D-mannan (0.625-5 μg/mL; 18 h (co-treated with FMDV antigen)), when co-treated with FMDV antigen for 18 h, significantly enhances IFNγ secretion in murine PECs and porcine PBMCs, indicating potent induction of innate and cellular immune responses[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

D-Galacto-D-mannan Related Antibodies
In Vivo

D-Galacto-D-mannan (100 µg/dose/mouse; i.m./p.o.; single dose) confers 100% survival in female C57BL/6 mice challenged with lethal FMDV, and induces significantly stronger early, intermediate and long-term humoral immune responses, when incorporated into a bivalent foot-and-mouth disease vaccine[1].
D-Galacto-D-mannan (1 mg/dose per pig; i.m.; booster immunization at 28 days after primary immunization) induces significantly stronger early, intermediate and long-term humoral immune responses in FMDV-seronegative Landrace pigs, with superior safety, as a component of the bivalent foot-and-mouth disease vaccine[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (female, 6-7 weeks old)[1]
Dosage: 100 µg/dose/mouse
Administration: i.m./p.o.; single dose
Result: Achieved 100% survival rate against both FMDV O/VET/2013 and FMDV A/Malay/97 challenges.
Caused no significant body weight change post-challenge.\nInduced significantly higher SP O ELISA antibody titers.
Induced significantly higher SP A ELISA antibody titers.
Induced significantly higher VN titers for O PA2.
Induced significantly higher VN titers for A YC.
Animal Model: Landrace (8-9 weeks old, FMDV type O and A antibody-seronegative)[1]
Dosage: 1 mg/dose/pig
Administration: intramuscular injection; booster dose at 28 days post-primary vaccination
Result: Induced significantly higher FMDV type O-specific SP O ELISA antibody titers at all sampling points, with peak titers at 42 dpv maintained through 84 dpv compared to control vaccine without D-galacto-D-mannan.
Induced significantly higher FMDV type A-specific SP A ELISA antibody titers that remained seropositive through 84 dpv.
Induced significantly higher VN titers for both O PA2 and A YC at all sampling points compared to control vaccine without D-galacto-D-mannan.
Induced significantly higher serum IgG and IgA concentrations at 56 dpv compared to control vaccine without D-galacto-D-mannan.
Caused no local side effects (granulomas or inflammation) at the vaccination site.
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[D-Galacto-D-mannan]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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D-Galacto-D-mannan Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

D-Galacto-D-mannan11078-30-1Carob galactomannanSirtuinDectin-2 agonistPBMCsPECsLandrace pigC57BL/6micefoot-and-mouth diseaseInhibitorinhibitorinhibit

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