Lnd 796
LND 796 is an aminosteroidal derivative with positive inotropic effects similar to those of digitalis. It exhibits electrophysiological, toxic, and inotropic effects in normal and partially potassium-depolarized ventricular muscles. LND 796 requires higher concentrations than digoxin to induce the same toxic symptoms. It exhibits a concentration-dependent positive inotropic effect on guinea pig papillary muscles in normal potassium solution. In partially potassium-depolarized papillary muscles, LND 796 enhances both components of contraction and increases the amplitude of slow action potentials. The mechanism of positive inotropic action of LND 796 involves enhanced calcium entry in calcium channels and inhibition of sodium-potassium ATPase. Due to its expanded positive inotropic range, LND 796 may have potential application in the treatment of congestive heart failure.
For research use only. We do not sell to patients.
- CAS No.: 118549-42-1
- Formula: C27H45NO7
- Molecular Weight:495.65
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
Chemical Information
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CAS No. 118549-42-1
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Molecular Weight 495.65
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Formula C27H45NO7
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SMILES
N[C@@]([C@@]12C)(CC[C@@H]1C(OC)=O)[C@@](CC[C@]3([H])C[C@H]4O[C@H](O[C@H]5C)[C@@H]([C@@H]([C@H]5O)O)O)([H])[C@@](CC2)([H])[C@]3(CC4)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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