1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. RS 67333 hydrochloride

RS 67333 hydrochloride 

Cat. No.: HY-101341
Handling Instructions

RS 67333 hydrochloride is a potent and selective 5-HT4 receptor (5-HT4R) partial agonist with a pKi of 8.7 in guinea-pig striatum. RS 67333 hydrochloride exhibits lower affinities at several other receptors including 5-HT1A, 5-HT1D, 5-HT2A, 5-HT2C, dopamine D1, D2 and muscarinic M1-M3 receptors. RS 67333 hydrochloride has neuroprotective effects, and can be used for Alzheimer's disease research.

For research use only. We do not sell to patients.

RS 67333 hydrochloride Chemical Structure

RS 67333 hydrochloride Chemical Structure

CAS No. : 168986-60-5

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Description

RS 67333 hydrochloride is a potent and selective 5-HT4 receptor (5-HT4R) partial agonist with a pKi of 8.7 in guinea-pig striatum. RS 67333 hydrochloride exhibits lower affinities at several other receptors including 5-HT1A, 5-HT1D, 5-HT2A, 5-HT2C, dopamine D1, D2 and muscarinic M1-M3 receptors. RS 67333 hydrochloride has neuroprotective effects, and can be used for Alzheimer's disease research[1].

IC50 & Target[1]

5-HT4 Receptor

8.7 (pKi)

In Vitro

RS 67333 hydrochloride does exhibit affinities for the sigma 1 (pKi = 8.9) and sigma 2 (pKi = 8.0) binding sites. At the 5-HT4 receptor mediating relaxation of the carbachol-precontracted oesophagus, RS 67333 hydrochloride acts as a potent (pEC50 of 8.4), partial agonists (intrinsic activities, with respect to 5-HT is 0.5) with respect to 5-HT[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

389.36

Formula

C19H30Cl2N2O2

CAS No.
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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
RS 67333 hydrochloride
Cat. No.:
HY-101341
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