1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. GR 113808

GR 113808 

Cat. No.: HY-103152
Handling Instructions

GR 113808 is a potent and highly selective 5-HT4 receptor antagonist (pKb= 8.8). GR 113808 shows 300-fold selectivity over 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C and 5-HT3 receptors.

For research use only. We do not sell to patients.

GR 113808 Chemical Structure

GR 113808 Chemical Structure

CAS No. : 144625-51-4

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Description

GR 113808 is a potent and highly selective 5-HT4 receptor antagonist (pKb= 8.8). GR 113808 shows 300-fold selectivity over 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C and 5-HT3 receptors[1].

In Vivo

GR113808 (intraperitoneal injection; 1 mg/kg; 5-7 days starting 24 h after induction of colitis) shows a significant increase in the disease activity index (DAI),which includes evaluation of weight loss, stool consistency, and presence of fecal blood[2].

Animal Model: Mice[1]
Dosage: 1 mg/Kg
Administration: Intraperitoneal  injection; 1 mg/Kg; 5-7 days starting 24 h after induction of colitis
Result: Blocked protective effects of tegaserod after induction of colitis.
Molecular Weight

393.50

Formula

C₁₉H₂₇N₃O₄S

CAS No.

144625-51-4

SMILES

O=C(C1=CN(C)C2=C1C=CC=C2)OCC3CCN(CCNS(=O)(C)=O)CC3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

GR 113808GR113808GR-1138085-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorcolitisInhibitorinhibitorinhibit

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