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Cat. No.: HY-W700638

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Benafentrine

Benafentrine is a phosphodiesterase 3 (PDE3) and phosphodiesterase 4 (PDE4) inhibitor with bronchodilator activity. Benafentrine has IC₅₀ values of 1.74 μM and 1.76 μM for guinea pig platelet PDE3 and neutrophil PDE4, respectively. Benafentrine can be used in research related to obstructive airway diseases.

For research use only. We do not sell to patients.

CAS No.: 35135-01-4
Formula: C₂₃H₂₇N₃O₃
Molecular Weight:393.49

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Benafentrine Chemical Structure

CAS No.: 35135-01-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

PDE3

1.74 μM (IC₅₀)

PDE4

1.76 μM (IC₅₀)

All Phosphodiesterase (PDE) Isoforms :

In Vitro

Benafentrine (compound 2) inhibits guinea-pig platelet PDE3 and guinea-pig neutrophil PDE4 with comparable potency, with IC₅₀ values of 1.74 μM and 1.76 μM respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 35135-01-4
Molecular Weight 393.49
Formula C₂₃H₂₇N₃O₃
SMILES

O(C)C=1C=C2C([C@]3([C@@](N=C2C4=CC=C(NC(C)=O)C=C4)(CCN(C)C3)[H])[H])=CC1OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Banner KH, et al. Dual PDE3/4 inhibitors as therapeutic agents for chronic obstructive pulmonary disease. Br J Pharmacol. 2009 Jul;157(6):892-906.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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