N-Glycolylneuraminic acid
Based on 1 Customer Validation
N-Glycolylneuraminic acid is a nonhuman sialic acid molecule synthesized in pigs but not in humans. N-Glycolylneuraminic acid works as a decoy receptor of N-Glycolylneuraminic acid-binding influenza A viruses (IAVs).
For research use only. We do not sell to patients.
- Purity: 99.76%
- CAS No.: 1113-83-3
- Formula: C11H19NO10
- Molecular Weight:325.27
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Endogenous Metabolite Isoforms
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Biological Activity
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Human Endogenous Metabolite |
N-Glycolylneuraminic acid (0.5-2 mM, 3 days) binds to the influenza virus HA protein, preventing the virus from entering A549 cell[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mouse 3LL Lewis lung carcinoma models[2]
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Dosage:
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Administration:sc, single dose
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Result:Increased the number of total lung tumor nodules and macronodules.
Chemical Information
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CAS No. 1113-83-3
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Appearance Solid
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Molecular Weight 325.27
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Formula C11H19NO10
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Color White to off-white
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SMILES
O[C@@]1(O[C@H]([C@@H]([C@H](C1)O)NC(CO)=O)[C@@H]([C@@H](CO)O)O)C(O)=O
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Synonyms
NeuGc; GcNeu
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
H2O : 83.33 mg/mL (256.19 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 10 mg/mL (30.74 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
Purity & Documentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Takahashi T, et al. N-glycolylneuraminic acid on human epithelial cells prevents entry of influenza A viruses that possess N-glycolylneuraminic acid binding ability. J Virol. 2014 Aug;88(15):8445-56. [Content Brief]
[2]. Segatori VI, et al., Preclinical evaluation of racotumomab, an anti-idiotype monoclonal antibody to N-glycolyl-containing gangliosides, with or without chemotherapy in a mouse model of non-small cell lung cancer. Front Oncol. 2012 Nov 8;2:160. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 3.0744 mL | 15.3718 mL | 30.7437 mL | 76.8592 mL |
| 5 mM | 0.6149 mL | 3.0744 mL | 6.1487 mL | 15.3718 mL | |
| 10 mM | 0.3074 mL | 1.5372 mL | 3.0744 mL | 7.6859 mL | |
| 15 mM | 0.2050 mL | 1.0248 mL | 2.0496 mL | 5.1239 mL | |
| 20 mM | 0.1537 mL | 0.7686 mL | 1.5372 mL | 3.8430 mL | |
| 25 mM | 0.1230 mL | 0.6149 mL | 1.2297 mL | 3.0744 mL | |
| 30 mM | 0.1025 mL | 0.5124 mL | 1.0248 mL | 2.5620 mL | |
| 40 mM | 0.0769 mL | 0.3843 mL | 0.7686 mL | 1.9215 mL | |
| 50 mM | 0.0615 mL | 0.3074 mL | 0.6149 mL | 1.5372 mL | |
| 60 mM | 0.0512 mL | 0.2562 mL | 0.5124 mL | 1.2810 mL | |
| 80 mM | 0.0384 mL | 0.1921 mL | 0.3843 mL | 0.9607 mL | |
| 100 mM | 0.0307 mL | 0.1537 mL | 0.3074 mL | 0.7686 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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