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N-Acetylneuraminic acid

(Synonyms: NANA; Lactaminic acid)
6 Cited Publications
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Based on 6 publication(s) in Google Scholar

N-Acetylneuraminic acid (NANA; Lactaminic acid), a nonphenolic structure, is the predominant form of sialic from Collocalia esculenta. N-Acetylneuraminic acid plays a biological role in myocardial injury, melanoma and viral or bacterial infection. N-Acetylneuraminic acid inhibits melanogenesis by reducing tyrosinase activity and triggers myocardial injury in vitro and in vivo by activation of the Rho/Rho-associated signaling pathway through binding to RhoA and Cdc42. N-Acetylneuraminic acid may prevent high fat diet (HFD)-induced inflammation and oxidative stress, thereby prevents hyperlipidemia-associated inflammation and oxidative stress. N-Acetylneuraminic acid is promising for research in the field of melanoma, coronary artery, obesity-related diseases and hyperlipidemia.

For research use only. We do not sell to patients.

  • Purity: 99.95%
  • CAS No.: 131-48-6
  • Formula: C11H19NO9
  • Molecular Weight:309.27
  • Storage:

    -20°C, stored under nitrogen

    * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

  • N-Acetylneuraminic acid Chemical Structure
    N-Acetylneuraminic acid Chemical Structure
  • Experimental Validation Results for N-Acetylneuraminic acid
  • Experimental Validation Results for N-Acetylneuraminic acid
  • Experimental Validation Results for N-Acetylneuraminic acid
  • Experimental Validation Results for N-Acetylneuraminic acid
  • Experimental Validation Results for N-Acetylneuraminic acid
CAS No.: 131-48-6
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  • N-Acetylneuraminic acid Chemical Structure
    N-Acetylneuraminic acid Chemical Structure
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    N-Acetylneuraminic acid purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2023 Jul:120:110410. [Abstract]

    Customer Validation
     Flow cytometry analysis of F4/80+CD80+ macrophage and ROS levels in RAW264.7 cells under the conditions of control and N-Acetylneuraminic acid (Neu5Ac) (30 mM).

  • 1/16

    N-Acetylneuraminic acid purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2023 Jul:120:110410. [Abstract]

    Customer Validation
     N-Acetylneuraminic acid (Neu5Ac) (15 mM) significantly increased mitoROS and oxidative DNA damage in RAW264.7 cells.

  • 1/16

    N-Acetylneuraminic acid purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2023 Jul:120:110410. [Abstract]

    Customer Validation
     The mRNA expression of CD80 and TNF-α (M1 markers) and ARG-1 and CD206 (M2 markers) following N-Acetylneuraminic acid (Neu5Ac) (5–20 mM) treatment. N-Acetylneuraminic acid (Neu5Ac) up-regulated the mRNA expression of M1 markers CD80 and TNF-α in RAW264.7 cells.

  • 1/16

    N-Acetylneuraminic acid purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2023 Jul:120:110410. [Abstract]

    Customer Validation
     Western blot of p-LKB1, p-AMPK, Sirt3 protein levels in RAW264.7 for different concentrations of N-Acetylneuraminic acid (Neu5Ac) (5-20 mM). N-Acetylneuraminic acid (Neu5Ac) inhibited the LKB1-AMPK-Sirt3 pathway the same as AC5 which led to ROS activation and M1 polarization.

  • 1/16

    N-Acetylneuraminic acid purchased from MedChemExpress. Usage Cited in: Int Immunopharmacol. 2023 Jul:120:110410. [Abstract]

    Customer Validation
     Immunostaining of CD68+ macrophages and IL-1beta in aortic sinuses harvested from APOE-/- mice subjected to CFD, CFD + N-Acetylneuraminic acid (Neu5Ac) (30 mg/kg; i.p.; once daily for 10 weeks), HFD, or HFD + N-Acetylneuraminic acid (Neu5Ac). N-Acetylneuraminic acid (Neu5Ac) notably increased the numbers of CD68+ macrophages and the expression of IL-1beta in aortic sinuses.

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