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  3. Tunicamycin

Tunicamycin 

Cat. No.: HY-A0098 Purity: 99.69%
Handling Instructions

Tunicamycin is a mixture of homologous nucleoside antibiotic that inhibits N-linked glycosylation and blocks GlcNAc phosphotransferase (GPT). Tunicamycin causes accumulation of unfolded proteins in cell endoplasmic reticulum (ER) and induces ER stress, and causes blocking of DNA synthesis and cell cycle arrest in G1 phase. Tunicamycin inhibits gram-positive bacteria, yeasts, fungi, and viruses and has anti-cancer activity.Tunicamycin increases exosome release in cervical cancer cells.

For research use only. We do not sell to patients.

Tunicamycin Chemical Structure

Tunicamycin Chemical Structure

CAS No. : 11089-65-9

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10 mg USD 650 In-stock
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Customer Review

Based on 18 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Tunicamycin purchased from MCE. Usage Cited in: Cell Death Dis. 2018 May 22;9(6):604.

    Western blot analysis of ER stress-related proteins after PPI treatment for 48 h in both pH 7.4 and pH 6.5 conditions. Cells treated with Thapsigargin (TG, 0.5 and 1 μM) or Tunicamycin (Tu, 2.5, 5 and 10 μg/mL) for 24 h served as positive controls.

    Tunicamycin purchased from MCE. Usage Cited in: PLoS Biol. 2018 Oct 18;16(10):e2006483. 

    SK-Hep1 cells stably expressing EV or Flag-PGM1 are treated with or without 0.1 ug/mL Tunicamycin, and cell proliferation is measured.
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    Description

    Tunicamycin is a mixture of homologous nucleoside antibiotic that inhibits N-linked glycosylation and blocks GlcNAc phosphotransferase (GPT). Tunicamycin causes accumulation of unfolded proteins in cell endoplasmic reticulum (ER) and induces ER stress, and causes blocking of DNA synthesis and cell cycle arrest in G1 phase. Tunicamycin inhibits gram-positive bacteria, yeasts, fungi, and viruses and has anti-cancer activity[1][2][3].Tunicamycin increases exosome release in cervical cancer cells[4].

    In Vitro

    Tunicamycin (2 µg/mL; 24 hours; CD44+/CD24- and original MCF7 cells) treatment increases the spliced XBP-1, ATF6 nuclear translocation level and CHOP protein expression in CD44+/CD24- and original MCF7 cells[1].
    Tunicamycin-induced ER stress suppresses CD44+/CD24- phenotype cell subpopulation and in vitro invasion and accelerates tumorosphore formation. Under effect of Tunicamycin, the results show that inhibited invasion, increased cell death, suppressed proliferation and reduced migration in the CD44+/CD24- and CD44+/CD24- rich MCF7 cell culture[1].

    Western Blot Analysis

    Cell Line: CD44+/CD24- and original MCF7 cells[1]
    Concentration: 2 µg/mL
    Incubation Time: 24 hours
    Result: Increased level of spliced XBP-1, ATF6 nuclear translocation and CHOP protein expression are detected in CD44+/CD24- and original MCF7 cells.
    In Vivo

    Tunicamycin (0.1 mg/kg or 0.5 mg/kg) treatment dramatically suppresses tumor growth in the CD133+/- MHCC97L cells xenograft model (BALB/c (nu/nu) mice)[2].

    Molecular Weight

    844.94 (n=10)

    Formula

    C₃₉H₆₄N₄O₁₆

    CAS No.

    11089-65-9

    SMILES
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 40 mg/mL (Need ultrasonic)

    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2 mg/mL (Infinity mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2 mg/mL (Infinity mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2 mg/mL (Infinity mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: 99.69%

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    Keywords:

    TunicamycinBacterialFungalInfluenza VirusAntibioticERUDP-HexNAcantibioticglycoproteinN-linkedDNAsynthesisanti-cancerXBP-1ATF6invasionInhibitorinhibitorinhibit

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