1. Anti-infection
  2. Bacterial

Tunicamycin 

Cat. No.: HY-A0098 Purity: 98.00%
Handling Instructions

Tunicamycin is a mixture of homologous nucleoside antibiotics.

For research use only. We do not sell to patients.

Tunicamycin Chemical Structure

Tunicamycin Chemical Structure

CAS No. : 11089-65-9

Size Price Stock Quantity
2 mg USD 72 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
5 mg USD 132 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
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Customer Review

    Tunicamycin purchased from MCE. Usage Cited in: Cell Death Dis. 2018 May 22;9(6):604.

    AGS cells are pretreated with 25 and 50 nM Bortezomib for 1 h, and then incubated with 500 nM Torin 1 for 24 h. After pretreatment with PPI for 24 h in pH 7.4 or pH 6.5 condition, Rapamycin (1 μM) or Torin 1 (500 nM) is added for another 24 h. The protein level of SQSTM1 is measured by western blot analysis.

    Tunicamycin purchased from MCE. Usage Cited in: Cell Death Dis. 2018 May 22;9(6):604.

    Western blot analysis of ER stress-related proteins after PPI treatment for 48 h in both pH 7.4 and pH 6.5 conditions. Cells treated with Thapsigargin (TG, 0.5 and 1 μM) or Tunicamycin (Tu, 2.5, 5 and 10 μg/mL) for 24 h served as positive controls.

    Tunicamycin purchased from MCE. Usage Cited in: Cell Death Dis. 2018 May 22;9(6):604.

    AGS cells transfected with HA-tagged SQSTM1 plasmid, are treated with 25 μg/mL Cycloheximide (CHX) over a 240-min time period or treated with 100 μg/mL PPI for 48 h in pH 7.4 conditions, and then followed by 25 μg/mL CHX over a 240-min time period.

    Tunicamycin purchased from MCE. Usage Cited in: Cell Death Dis. 2018 May 22;9(6):604.

    Different concentrations of two classical proteasome inhibitors Bortezomib and MG132 are added. AGS cells are either untreated or treated with Bortezomib (25 nM) or MG132 (0.1 μM) for 24 h in the absence or presence of baf A1 (100 nM).
    • Biological Activity

    • Technical Information

    • Purity & Documentation

    • References

    Description

    Tunicamycin is a mixture of homologous nucleoside antibiotics. An inhibitor of glycosylation. Tunicamycin Blocks the formation of N-glycosidic linkages by inhibiting the first step in glycoprotein synthesis. In vitro: Tunicamycin causes accumulation of unfolded proteins in cell endoplasmic reticulum (ER). Tunicamycin-induced ER stress suppresses CD44+/CD24- phenotype cell subpopulation. Tunicamycin inhibite invasion, increase cell death, suppress proliferation and reduce migration in the CD44+/CD24- and CD44+/CD24- rich MCF7 cell culture. [1] In vivo: Administering tunicamycin further increase protein expression levels of ER stress indicators and inflammatory cytokines, and resulted in more severe asthma phenotypes in OVALPS-OVA mice. [2]

    References
    Molecular Weight

    844.94 (n=10)

    Formula

    C₃₉H₆₄N₄O₁₆ (n=₁₀)

    CAS No.

    11089-65-9

    SMILES

    O=C1NC(N([[email protected]]2[[email protected]](O)[[email protected]](O)[[email protected]@H](C(C[[email protected]@H]3[[email protected]](O)[[email protected]](O)[[email protected]@H](NC(/C=C/[(CH2) 8-11]C(C)C)=O)[[email protected]](O[[email protected]]4O[[email protected]](CO)[[email protected]@H](O)[[email protected]](O)[[email protected]]4NC(C)=O)O3)O)O2)C=C1)=O

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Shipping

    Room temperature in continental US; may vary elsewhere

    Solvent & Solubility

    10 mM in DMSO

    * "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

    Purity: 98.00%

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    Product Name:
    Tunicamycin
    Cat. No.:
    HY-A0098
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