Mechanisms associated with biogenesis of exosomes in cancer

  • Mol Cancer. 2019 Mar 30;18(1):52. doi: 10.1186/s12943-019-0963-9.
Kathleen M McAndrews  1 ,  Raghu Kalluri  2
Affiliations
  • 1. Department of Cancer Biology, Metastasis Research Center, University of Texas, MD Anderson Cancer Center, Unit 1906, 1881 East Road, Houston, TX, 77054, USA. [email protected].
  • 2. Department of Cancer Biology, Metastasis Research Center, University of Texas, MD Anderson Cancer Center, Unit 1906, 1881 East Road, Houston, TX, 77054, USA. [email protected].
PMID: 30925917 DOI: 10.1186/s12943-019-0963-9
Abstract

Intercellular communication between cellular compartments within the tumor and at distant sites is critical for the development and progression of Cancer. Exosomes have emerged as potential regulators of intracellular communication in Cancer. Exosomes are nanovesicles released by cells that contain biomolecules and are exchanged between cells. Exchange of exosomes between cells has been implicated in a number of processes critical for tumor progression and consequently altering exosome release is an attractive therapeutic target. Here, we review current understanding as well as gaps in knowledge regarding regulators of exosome release in Cancer.

Keywords
Biogenesis; Cancer; Exosomes.
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