2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Hypoxanthine

Hypoxanthine  (Synonyms: Purin-6-ol; Sarcine)

Cat. No.: HY-N0091 Purity: 99.95%
COA Handling Instructions

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Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.

For research use only. We do not sell to patients.

Hypoxanthine Chemical Structure

Hypoxanthine Chemical Structure

CAS No. : 68-94-0

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10 mM * 1 mL in DMSO
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Based on 5 publication(s) in Google Scholar

Other Forms of Hypoxanthine:

Hypoxanthine Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.

IC50 & Target

Microbial Metabolite

 

Human Endogenous Metabolite

 

In Vitro

Hypoxanthine is a potential free radical generator. Hypoxanthine seems to play a role in posthypoxic reoxygenation cell injury through oxygen radical production and is therefore involved in the pathogenesis of a number of diseases. Hypoxanthine also modulates a number of other processes because it reacts with benzodiazepine receptors and inhibits phosphodiesterase in the brain. Hypoxanthine inhibits the effect of several cytotoxic drugs and may therefore influence treatment with such drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Hypoxanthine Related Antibodies
In Vivo

In pigs, a linear increase of plasma hypoxanthine with duration of hypoxemia is found, and there is no difference between arterial and venous plasma. There are good correlations between hypoxanthine and lactate, base deficit and pH. There is also a direct relationship between survival time and increase in plasma hypoxanthine. Survival time correlates negatively with the rate of hypoxanthine increase (r=-0.62).All animals die when hypoxanthine exceeds 125 pM/liter. The increase of hypoxanthine therefore reflected the prognosis of acute hypoxia in contrast to base deficit[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

136.11

Formula

C5H4N4O
CAS No.
Appearance

Solid

Color

Off-white to pink

SMILES

O=C1NC=NC2=C1N=CN2
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (73.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.3470 mL 36.7350 mL 73.4700 mL
5 mM 1.4694 mL 7.3470 mL 14.6940 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  0.5% CMC-Na/saline water

    Solubility: 25 mg/mL (183.67 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.95%

COA (251 KB) HNMR (123 KB) RP-HPLC (242 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 7.3470 mL 36.7350 mL 73.4700 mL 183.6750 mL
5 mM 1.4694 mL 7.3470 mL 14.6940 mL 36.7350 mL
10 mM 0.7347 mL 3.6735 mL 7.3470 mL 18.3675 mL
15 mM 0.4898 mL 2.4490 mL 4.8980 mL 12.2450 mL
20 mM 0.3673 mL 1.8367 mL 3.6735 mL 9.1837 mL
25 mM 0.2939 mL 1.4694 mL 2.9388 mL 7.3470 mL
30 mM 0.2449 mL 1.2245 mL 2.4490 mL 6.1225 mL
40 mM 0.1837 mL 0.9184 mL 1.8367 mL 4.5919 mL
50 mM 0.1469 mL 0.7347 mL 1.4694 mL 3.6735 mL
60 mM 0.1224 mL 0.6122 mL 1.2245 mL 3.0612 mL
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Hypoxanthine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hypoxanthine68-94-0Purin-6-ol SarcineEndogenous MetaboliteInhibitorinhibitorinhibit

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