1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite

Hypoxanthine (Synonyms: Purin-6-ol; Sarcine; Sarkin; Sarkine)

Cat. No.: HY-N0091 Purity: 99.94%
Handling Instructions

Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.

For research use only. We do not sell to patients.

Hypoxanthine Chemical Structure

Hypoxanthine Chemical Structure

CAS No. : 68-94-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 50 In-stock
Estimated Time of Arrival: December 31
50 mg USD 40 In-stock
Estimated Time of Arrival: December 31
100 mg USD 50 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Hypoxanthine, a purine derivative, is a potential free radical generator and could be used as an indicator of hypoxia.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Hypoxanthine is a potential free radical generator. Hypoxanthine seems to play a role in posthypoxic reoxygenation cell injury through oxygen radical production and is therefore involved in the pathogenesis of a number of diseases. Hypoxanthine also modulates a number of other processes because it reacts with benzodiazepine receptors and inhibits phosphodiesterase in the brain. Hypoxanthine inhibits the effect of several cytotoxic drugs and may therefore influence treatment with such drugs[1].

In Vivo

In pigs, a linear increase of plasma hypoxanthine with duration of hypoxemia is found, and there is no difference between arterial and venous plasma. There are good correlations between hypoxanthine and lactate, base deficit and pH. There is also a direct relationship between survival time and increase in plasma hypoxanthine. Survival time correlates negatively with the rate of hypoxanthine increase (r=-0.62).All animals die when hypoxanthine exceeds 125 pM/liter. The increase of hypoxanthine therefore reflected the prognosis of acute hypoxia in contrast to base deficit[1].

Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (73.47 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.3470 mL 36.7350 mL 73.4700 mL
5 mM 1.4694 mL 7.3470 mL 14.6940 mL
10 mM 0.7347 mL 3.6735 mL 7.3470 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

136.11

Formula

C₅H₄N₄O

CAS No.

68-94-0

SMILES

O=C1NC=NC2=C1N=CN2

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
Hypoxanthine
Cat. No.:
HY-N0091
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Hypoxanthine

Cat. No.: HY-N0091