1. Anti-infection
    Metabolic Enzyme/Protease
  2. HSV
    Endogenous Metabolite
  3. Guanosine

Guanosine (Synonyms: DL-Guanosine; Vernine)

Cat. No.: HY-N0097 Purity: >98.0%
Handling Instructions

Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity.

For research use only. We do not sell to patients.

Guanosine Chemical Structure

Guanosine Chemical Structure

CAS No. : 118-00-3

Size Price Stock Quantity
10 mM * 1  mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
500 mg USD 50 In-stock
Estimated Time of Arrival: December 31
1 g USD 60 In-stock
Estimated Time of Arrival: December 31
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10 g   Get quote  

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Customer Review

Based on 5 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Guanosine purchased from MCE. Usage Cited in: Molecules. 2019 May 3;24(9). pii: E1723.

    Guanosine supplementation attenuated the anti-FMDV effect of mizoribine. Serial dilutions of guanosine (from 100 to 25 μM) are added to FMDV (100 TCID50 O/MY98/BY/2010)-infected IBRS-2 cells, when treated with 75 μM mizoribine for 48 h. (A) The cell viability of cells and (B) FMDV VP1 levels are analyzed.

    Guanosine purchased from MCE. Usage Cited in: Mol Immunol. 2019 Oct;114:226-232.

    The viral VP1 protein and β-actin are detected by western blot. β-actin was used as an internal control. A serial dilution of guanosine (from 100 μM to 25μM) are added to FMDV infected IBRS-2 cells, when treated with 25 μM merimepodib for 48 h. Cell viability and VP1 protein is analysed as described above.
    • Biological Activity

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    Description

    Guanosine (DL-Guanosine) is a purine nucleoside comprising guanine attached to a ribose (ribofuranose) ring via a β-N9-glycosidic bond. Guanosine possesses anti-HSV activity.

    IC50 & Target

    Human Endogenous Metabolite

     

    In Vitro

    Guanosine can be phosphorylated to become guanosine monophosphate (GMP), cyclic guanosine monophosphate (cGMP), guanosine diphosphate (GDP), and guanosine triphosphate (GTP). These forms play important roles in various biochemical processes such as synthesis of nucleic acids and proteins, photosynthesis, muscle contraction, and intracellular signal transduction (cGMP).

    Molecular Weight

    283.24

    Formula

    C₁₀H₁₃N₅O₅

    CAS No.

    118-00-3

    SMILES
    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    4°C, protect from light

    *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (353.06 mM; Need ultrasonic)

    H2O : 1 mg/mL (3.53 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.5306 mL 17.6529 mL 35.3057 mL
    5 mM 0.7061 mL 3.5306 mL 7.0612 mL
    10 mM 0.3531 mL 1.7653 mL 3.5306 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (8.83 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (8.83 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (8.83 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References

    Purity: >98.0%

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    • Molarity Calculator

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    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    GuanosineDL-GuanosineVernineHSVEndogenous MetaboliteHerpes simplex virusInhibitorinhibitorinhibit

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    Product name:
    Guanosine
    Cat. No.:
    HY-N0097
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