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  4. High Uric Acid Models
  5. Potassium oxonate

Potassium oxonate  (Synonyms: Potassium azaorotate; Potassium otastat; Oteracil potassium)

Cat. No.: HY-17511 Purity: 99.94%
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Potassium oxonate (Potassium azaorotate) is a uricase inhibitor that inhibits the phosphorylation of 5-FU to 5-fluorouridine-5'-monophosphate.

For research use only. We do not sell to patients.

CAS No. : 2207-75-2

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10 mM * 1 mL in Water
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Based on 13 publication(s) in Google Scholar

Potassium oxonate Related Antibodies

Top Publications Citing Use of Products

    Potassium oxonate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Apr;12(16):e2415041.  [Abstract]

    Mice were orally administered 250 mg/kg Potassium oxonate by gavage once daily. Representative confocal images of hair cells stained with Myosin 7a (red) and DAPI (blue) in mice cochleae were shown for each group.

    Potassium oxonate purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Apr;12(16):e2415041.  [Abstract]

    Mice were orally administered 250 mg/kg of potassium oxonate by gavage once daily. ABR thresholds in each group (n = 3) were recorded. The statistical differences were analyzed between the noise exposure + UA + PO group and the noise exposure group.

    Potassium oxonate purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2024 Aug 20;5(8):101690.  [Abstract]

    To establish the HN mouse model, adenine (0.16 g/kg) and potassium oxonate (2.4 g/kg) mixture (dissolved in a 0.5% CMC Na solution) were orally administered every other day for four weeks. Representative western blots of α-SMA and FN1 protein and quantification of protein levels normalized to β-actin in isolated renal tubules from each mouse group were shown.

    Potassium oxonate purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2024 Aug 20;5(8):101690.  [Abstract]

    To establish the HN mouse model, adenine (0.16 g/kg) and potassium oxonate (2.4 g/kg) mixture (dissolved in a 0.5% CMC Na solution) were orally administered every other day for four weeks. Representative images of αSMA (green), FN1 (red) immunofluorescent staining and quantitation of fluorescence intensity in kidney sections from each mouse group were shown.

    Potassium oxonate purchased from MedChemExpress. Usage Cited in: Cell Rep Med. 2024 Aug 20;5(8):101690.  [Abstract]

    Serum UA, Cr, and BUN levels in each mouse group were measured. To establish the HN mouse model, adenine (0.16 g/kg) and potassium oxonate (2.4 g/kg) mixture (dissolved in a 0.5% CMC Na solution) were orally administered every other day for four weeks.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Potassium oxonate (Potassium azaorotate) is a uricase inhibitor that inhibits the phosphorylation of 5-FU to 5-fluorouridine-5'-monophosphate.

    In Vivo

    Note:
    Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.

    Potassium oxonate can be used in animal modeling to create hyperuricemia models. After metabolism, Potassium oxonate primarily distributes within the cells of the small intestine. In the gastrointestinal tract, Potassium oxonate is converted to cyanuric acid via two pathways: the first involves direct conversion by gut microbiota in the cecum, and the second involves conversion through xanthine oxidase, or after degradation by stomach acid into 5-aza-uracil (5-AZU), followed by conversion through aldehyde oxidase[3].

    Induction of High Uric Acid[4]
    Background
    Potassium oxonate is a selective competitive uricase inhibitor that blocks the action of hepatic uricase.
    Specific Modeling Methods
    Mice : Kunming • male • 18-22 g
    Administration: 300 mg/kg • i.p. • once daily for 14 days
    Note
    (1) The animals are adapted to the environment for 1 week before the experiment. All animals have access to a standard diet and water ad libitum and are acclimated to specific pathogen-free (SPF) conditions of 22 ± 2 °C, 60 ± 5% humidity, and a fixed 12-h artificial light period.
    (2) On day 15, the mice are fasted for 12 hours, anesthetized with pentobarbital sodium, and then all sacrificed.
    (3) Collect mouse blood samples in 2mL EP tubes, centrifuge (3000rpm, 4°C, 10min), and then store at -80°C for biochemical determination.
    (4) The kidney tissue is quickly removed, weighed and divided into two parts, one part was fixed in 4% paraformaldehyde for histopathological examination, and the other part is stored at -80°C for further biochemical determination.
    Modeling Indicators
    Molecular changes: Increased the levels of CRE, BUN, MDA, XOD and UA. Reduced the levels of SOD and GSH-Px in serum. Increased the levels of IL-1β and IL-18 in both serum and kidney and the mRNA expressions of IL-1β, NLRP3, ASC and caspase1.
    Histological changes: Inconspicuous boundaries between adjacent proximal tubule cells, swelling and proximal tubule necrosis.
    Correlated Product(s): Hypoxanthine (HY-N0091)
    Opposite Product(s): Curcumin (HY-N0005)

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Clinical Trial
    Molecular Weight

    195.17

    Formula

    C4H2KN3O4
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    O=C(O[K])C1=NC(O)=NC(O)=N1
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 3.33 mg/mL (17.06 mM; ultrasonic and warming and heat to 60°C)

    DMSO : < 1 mg/mL (insoluble or slightly soluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 5.1237 mL 25.6187 mL 51.2374 mL
    5 mM 1.0247 mL 5.1237 mL 10.2475 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo:

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 10 mg/mL (51.24 mM); Suspended solution; Need ultrasonic and warming and heat to 60°C

    • Protocol 2

      Add each solvent one by one:  0.5% CMC-Na/saline water

      Solubility: 5 mg/mL (25.62 mM); Suspended solution; Need ultrasonic and warming

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.94%

    SDS (393 KB)

    COA (249 KB) RP-HPLC (244 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 5.1237 mL 25.6187 mL 51.2374 mL 128.0935 mL
    5 mM 1.0247 mL 5.1237 mL 10.2475 mL 25.6187 mL
    10 mM 0.5124 mL 2.5619 mL 5.1237 mL 12.8093 mL
    15 mM 0.3416 mL 1.7079 mL 3.4158 mL 8.5396 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Potassium oxonate Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Potassium oxonate2207-75-2Potassium azaorotate Potassium otastatOteracilXanthine OxidaseXOInhibitorinhibitorinhibit

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