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Potassium oxonate (Synonyms: Potassium azaorotate; Potassium otastat)

Cat. No.: HY-17511 Purity: 99.82%
Handling Instructions

Potassium oxonate is an inhibitor of uricase, inhibits the phosphorylation of 5-FU to 5-fluorouridine-5'-monophosphate catalyzed by pyrimidine phosphoribosyl-transferase in a different manner from allopurinol in cell-free extracts and intact cells in vitro.

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Potassium oxonate Chemical Structure

Potassium oxonate Chemical Structure

CAS No. : 2207-75-2

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Based on 1 publication(s) in Google Scholar

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Description

Potassium oxonate is an inhibitor of uricase, inhibits the phosphorylation of 5-FU to 5-fluorouridine-5'-monophosphate catalyzed by pyrimidine phosphoribosyl-transferase in a different manner from allopurinol in cell-free extracts and intact cells in vitro. IC50 value: Target: On p.o. administration of 5-FU (2 mg/kg) and a potent inhibitor of 5-FU degradation to Yoshida sarcoma-bearing rats, oxonic acid (10 mg/kg) was found to inhibit the formation of 5-fluorouridine-5'-monophosphate from 5-FU and its subsequent incorporation into the RNA fractions of small and large intestine but not of tumor and bone marrow tissues [1]. Oxonic acid diet increased plasma uric acid by 80-90 micromol/l, while blood pressure was elevated only in hyperuricemic 5/6 nephrectomy rats (18 mmHg) [2].

Molecular Weight

195.17

Formula

C₄H₂KN₃O₄

CAS No.

2207-75-2

SMILES

O=C(O[K])C1=NC(O)=NC(O)=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 9.09 mg/mL (46.57 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.1237 mL 25.6187 mL 51.2374 mL
5 mM 1.0247 mL 5.1237 mL 10.2475 mL
10 mM 0.5124 mL 2.5619 mL 5.1237 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  0.5% CMC-Na/saline water

    Solubility: 25 mg/mL (128.09 mM); Suspended solution; Need ultrasonic and warming

*All of the co-solvents are provided by MCE.
References

Purity: 99.82%

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

Keywords:

Potassium oxonatePotassium azaorotate Potassium otastatOthersInhibitorinhibitorinhibit

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Product Name:
Potassium oxonate
Cat. No.:
HY-17511
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