1. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  2. DNA/RNA Synthesis Endogenous Metabolite
  3. Guanine

Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool.

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Guanine Chemical Structure

Guanine Chemical Structure

CAS No. : 73-40-5

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Based on 3 publication(s) in Google Scholar

Other Forms of Guanine:

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Description

Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool[1].

IC50 & Target

Human Endogenous Metabolite

 

Microbial Metabolite

 

Molecular Weight

151.13

Formula

C5H5N5O

CAS No.
Unlabeled CAS

Appearance

Solid

Color

White to off-white

SMILES

O=C1N=C(N)NC2=C1NC=N2

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

0.5 M NaOH : 10 mg/mL (66.17 mM; ultrasonic and adjust pH to 12 with NaOH)

H2O : 1 mg/mL (6.62 mM; ultrasonic and warming and heat to 80°C)

DMSO : 0.15 mg/mL (0.99 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.6168 mL 33.0841 mL 66.1682 mL
5 mM 1.3234 mL 6.6168 mL 13.2336 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / 0.5 M NaOH 1 mM 6.6168 mL 33.0841 mL 66.1682 mL 165.4205 mL
5 mM 1.3234 mL 6.6168 mL 13.2336 mL 33.0841 mL
0.5 M NaOH 10 mM 0.6617 mL 3.3084 mL 6.6168 mL 16.5420 mL
15 mM 0.4411 mL 2.2056 mL 4.4112 mL 11.0280 mL
20 mM 0.3308 mL 1.6542 mL 3.3084 mL 8.2710 mL
25 mM 0.2647 mL 1.3234 mL 2.6467 mL 6.6168 mL
30 mM 0.2206 mL 1.1028 mL 2.2056 mL 5.5140 mL
40 mM 0.1654 mL 0.8271 mL 1.6542 mL 4.1355 mL
50 mM 0.1323 mL 0.6617 mL 1.3234 mL 3.3084 mL
60 mM 0.1103 mL 0.5514 mL 1.1028 mL 2.7570 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Guanine
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