Guanine-¹³C

Name: Guanine- 13 C
Brand: MedChemExpress
SKU: HY-Y1055S
Rating: 4.5 (1 reviews)

Cat. No.: HY-Y1055S Purity: 99.5%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Guanine-¹³C is the ¹³C labeled Guanine (HY-Y1055). Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects.

For research use only. We do not sell to patients.

Guanine-¹³C Chemical Structure

CAS No. : 201489-20-5

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Guanine-¹³C:

Guanine In-stock
Guanine (Standard) In-stock

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All DNA/RNA Synthesis Isoform Specific Products:

View All Isoforms

RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

View All Endogenous Metabolite Isoform Specific Products:

View All Isoforms

Human Endogenous Metabolite Microbial Metabolite

Biological Activity
Purity & Documentation
References
Customer Review

Description

Guanine-¹³C is the ¹³C labeled Guanine (HY-Y1055)^[1]. Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects^[1]^[2]^[3]^[4].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

IC₅₀ & Target^[1]

Human Endogenous Metabolite

Microbial Metabolite

Fungal Metabolite

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

152.12

Formula

C₄¹³CH₅N₅O

CAS No.

201489-20-5

Unlabeled CAS

73-40-5

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C2=C(N=[13CH]N2)NC(N)=N1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

1 M NaOH : 50 mg/mL (328.69 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.5738 mL	32.8688 mL	65.7376 mL
5 mM	1.3148 mL	6.5738 mL	13.1475 mL
10 mM	0.6574 mL	3.2869 mL	6.5738 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.5%

Select Batch:

Data Sheet (273 KB) SDS (394 KB)

COA (248 KB)

Handling Instructions (2659 KB)

References

[1]. Mojzeš P, et al. Guanine, a high-capacity and rapid-turnover nitrogen reserve in microalgal cells. Proc Natl Acad Sci U S A. 2020 Dec 22;117(51):32722-32730. [Content Brief]

[2]. Chauhan V, et al. In Silico Discovery and Validation of Amide Based Small Molecule Targeting the Enzymatic Site of Shiga Toxin. J Med Chem. 2016 Dec 8;59(23):10763-10773. [Content Brief]

[3]. Messina E, et al. Guanine nucleotide depletion triggers cell cycle arrest and apoptosis in human neuroblastoma cell lines. Int J Cancer. 2004 Mar 1;108(6):812-7. [Content Brief]

[4]. de Oliveira ED, et al. Mechanisms involved in the antinociception induced by spinal administration of inosine or guanine in mice. Eur J Pharmacol. 2016 Feb 5;772:71-82. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

1 M NaOH	1 mM	6.5738 mL	32.8688 mL	65.7376 mL	164.3439 mL
	5 mM	1.3148 mL	6.5738 mL	13.1475 mL	32.8688 mL
	10 mM	0.6574 mL	3.2869 mL	6.5738 mL	16.4344 mL
	15 mM	0.4383 mL	2.1913 mL	4.3825 mL	10.9563 mL
	20 mM	0.3287 mL	1.6434 mL	3.2869 mL	8.2172 mL
	25 mM	0.2630 mL	1.3148 mL	2.6295 mL	6.5738 mL
	30 mM	0.2191 mL	1.0956 mL	2.1913 mL	5.4781 mL
	40 mM	0.1643 mL	0.8217 mL	1.6434 mL	4.1086 mL
	50 mM	0.1315 mL	0.6574 mL	1.3148 mL	3.2869 mL
	60 mM	0.1096 mL	0.5478 mL	1.0956 mL	2.7391 mL
	80 mM	0.0822 mL	0.4109 mL	0.8217 mL	2.0543 mL
	100 mM	0.0657 mL	0.3287 mL	0.6574 mL	1.6434 mL

Guanine-¹³C Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Guanine-¹³C201489-20-5DNA/RNA SynthesisEndogenous MetaboliteInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Requested Quantity *

Applicant Name *

Salutation

Email Address *

Phone Number *

Department

Organization Name *

City

State

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *

Organization Name *

Country or Region *

Remarks

Name
Email *

	Sorry, but the email address you supplied was invalid.

Guanine-13C

Customer Review

Other Forms of Guanine-13C:

Guanine-13C Related Antibodies

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All DNA/RNA Synthesis Isoform Specific Products:

View All Endogenous Metabolite Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Guanine-13C Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Guanine-13C Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report

Guanine-¹³C

Other Forms of Guanine-¹³C:

Guanine-¹³C Related Antibodies

Guanine-¹³C Related Antibodies

Guanine-¹³C Related Classifications