1. GPCR/G Protein
  2. Leukotriene Receptor
  3. LY255283

LY255283 

Cat. No.: HY-15744 Purity: >98.0%
Handling Instructions

LY255283 is a LTB4 receptor (BLT2) antagonist, with an IC50 of ~100 nM for [3H]LTB4 binding to guinea pig lung membranes.

For research use only. We do not sell to patients.

LY255283 Chemical Structure

LY255283 Chemical Structure

CAS No. : 117690-79-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 413 In-stock
Estimated Time of Arrival: December 31
5 mg USD 375 In-stock
Estimated Time of Arrival: December 31
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Description

LY255283 is a LTB4 receptor (BLT2) antagonist, with an IC50 of ~100 nM for [3H]LTB4 binding to guinea pig lung membranes[1][2][3][4].

IC50 & Target[2]

LTB4

~100 nM (IC50, LTB4 binds to guinea pig lung membranes)

In Vitro

LY255283 competitively reduces conlractilc responses of lung parcnchyma to LTB, (pA2 = 7.2)[2].
LY255283 (10 μM, 7 days) significantly suppresses the invasiveness of highly aggressive 253 J-BV bladder cancer cells[4].

Cell Viability Assay[4]

Cell Line: 253 J-BV cells.
Concentration: 5 or 10 μM.
Incubation Time: 7 days.
Result: Inhibition of BLT2 signaling attenuates aggressive migration by 253 J-BV cells.
In Vivo

LY255283 (3, 30 mg/kg) ameliorates lipopolysaccharide-induced ARDS in pigs, possibly by blocking the recruitment of activated PMNs into alveoli in a dose-dependent fashion[3].
LY255283 (2.5 mg/kg, ip) inhibits transitional cell carcinoma metastasis in mice models. The result suggests that a BLT2–Nox–ROS–NF–κB cascade plays a critical role in bladder cancer invasion and metastasis[4].

Animal Model: Mice (253 J-BV cells injected)[4].
Dosage: 2.5 mg/kg.
Administration: IP injected 3 and 5 days after injection of cells.
Result: By 12 weeks after injection, in mice treated with LY255283 only 0-3 nodules formed per lung, and histological analysis confirmed that the number of micrometastatic lesions was markedly reduced.
Molecular Weight

360.45

Formula

C₁₉H₂₈N₄O₃

CAS No.

117690-79-6

SMILES

CC(C1=CC(CC)=C(OCCCCCC(C2=NNN=N2)(C)C)C=C1O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

References

Purity: >98.0%

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Keywords:

LY255283LY 255283LY-255283Leukotriene ReceptorLTB4BLT2253-J-BVlungparcnchymaInhibitorinhibitorinhibit

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LY255283
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HY-15744
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