country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-13527A

Copy Link Print Information

LY310762 free base

Name: LY310762 free base
Brand: MedChemExpress
SKU: HY-13527A
Availability: PreOrder

1 Cited Publications

Customer Review

Based on 1 publication(s) in Google Scholar

LY310762 free base is a selective 5-HT_1D receptor antagonist with a K_i value of 249 nM for the guinea pig receptor. LY310762 free base blocks presynaptic 5-HT_1D autoreceptors and enhances potassium-stimulated [³H]5-HT outflow from guinea pig cortical slices. LY310762 free base abolishes the inhibitory effect of 5-CT (HY-135555)/L-694,247 (HY-101208) on sympathetic nerve-induced renal vasoconstriction mediated by prejunctional 5-HT_1D receptors. LY310762 free base potentiates the increase in extracellular 5-HT concentration induced by Fluoxetine (HY-B0102). LY310762 free base is used in research related to depression and diabetic nephropathy.

For research use only. We do not sell to patients.

CAS No.: 379215-96-0
Formula: C₂₄H₂₇FN₂O₂
Molecular Weight:394.48

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

LY310762 free base Chemical Structure

CAS No.: 379215-96-0

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

5-HT_1D Receptor

249 nM (Ki)

All 5-HT Receptor Isoforms :

In Vitro

LY310762 (1000 nM) shows preferential affinity for the guinea pig 5-HT_1D receptor (K_i = 249 nM) over the guinea pig 5-HT_1B receptor^[1].
LY310762 potentiates potassium-stimulated [³H]5-HT release from guinea pig cortical slices with an EC₅₀ of 31 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

LY310762 (10 mg/kg; i.p.; single administration) free base enhances the Fluoxetine (HY-B0102)-induced increase in extracellular 5-HT in the guinea pig hypothalamus^[1].
LY310762 (1 mg/kg; i.v.) free base alone does not alter electrically stimulated-induced pressor responses in Fluoxetine-treated decerebrate rats^[3].
LY310762 (1 mg/kg; i.v.) free base blocks the sympathoinhibitory effect of the 5-HT_1D agonist L-694,247 (HY-101208), confirming the involvement of presynaptic 5-HT_1D receptors in Fluoxetine-treated rats^[3].
LY310762 (1 mg/kg; i.v.) free base, when combined with the 5-HT1A antagonist WAY-100,635, eliminates 5-HT-induced sympathoinhibition in Fluoxetine-treated rats, confirming the involvement of both presynaptic 5-HT_1A and 5-HT_1D receptors^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Dunkin Hartley (female, 350-400 g)^[1]
Dosage:

10 mg/kg (after Fluoxetine); 10 mg/kg (alone)
Administration:

i.p.; single administration
Result:

Increased extracellular 5-HT levels from 312% to a maximum of 683% in fluoxetine-treated animals.
Increased basal 5-HT levels to a maximum of 258% when administered alone.

Chemical Information

CAS No. 379215-96-0
Molecular Weight 394.48
Formula C₂₄H₂₇FN₂O₂
SMILES

O=C(C1CCN(CC1)CCN2C(C(C)(C)C3=C2C=CC=C3)=O)C4=CC=C(C=C4)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

All

Sort by:

Journal Impact Factor

Authorea

September 19, 2022.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Pullar IA, et al. The role of the 5-HT1D receptor as a presynaptic autoreceptor in the guinea pig. European journal of pharmacology. 2004 Jun 16;493(1-3):85-93. [Content Brief]

[2]. Fernández-González JF, et al. Renal Sympathetic Hyperactivity in Diabetes Is Modulated by 5-HT Receptor Activation via NO Pathway. International journal of molecular sciences. 2023 Jan 10;24(2):1378.

[3]. García-Pedraza JÁ, et al. Vascular sympathetic neurotransmission and its serotonergic regulation are modified by chronic fluoxetine treatment. Journal of pharmacological sciences. 2021 Sep;147(1):48-57.

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

LY310762 free base

1 Cited Publications

100 mg Get Quote

Subscribe to the

MedChemExpress

Newsletter

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote

Amount: USD 0.00

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Purity & Documentation
References

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Product Name:
CAS No.:
Species:
Purity:
Quantity:

LY310762 free base

Publications Citing Use of MedChemExpress (MCE) LY310762 free base

All 5-HT Receptor Isoforms