Substance P (3-11)
Substance P (3-11) is a substance P (SP) fragment peptide that can cross the BBB. Substance P (3-11) has contracting activities on guinea pig ileum. Substance P (3-11) also promotes human monocyte chemotaxis .
For research use only. We do not sell to patients.
- CAS No.: 51165-11-8
- Formula: C52H79N13O11S
- Molecular Weight:1094.33
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Substance P (3-11) permeates the BBMEC monolayers with permeation rate (cm/s) of 1.92 x 105[2].
Substance P (3-11) promotes human monocyte chemotaxis in a modified Boyden chamber assay[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 51165-11-8
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Molecular Weight 1094.33
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Formula C52H79N13O11S
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Sequence
Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
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Sequence Shortening
KPQQFFGLM-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Yanaihara N, et al. Immunological aspects of secretin, substance P, and VIP. Gastroenterology. 1977 Apr;72(4 Pt.2):803-10. [Content Brief]
[2]. Chappa AK, et al. Characteristics of substance P transport across the blood-brain barrier. Pharm Res. 2006 Jun;23(6):1201-8. [Content Brief]
[3]. Ruff MR, et al. Substance P receptor-mediated chemotaxis of human monocytes. Peptides. 1985;6 Suppl 2:107-11. [Content Brief]
[4]. Sertl K, et al. Substance P: the relationship between receptor distribution in rat lung and the capacity of substance P to stimulate vascular permeability. Am Rev Respir Dis. 1988 Jul;138(1):151-9. [Content Brief]
[5]. Freed AL, et al. Investigation of substance P transport across the blood-brain barrier. Peptides. 2002 Jan;23(1):157-65. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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