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[Leu5]-Enkephalin

(Synonyms: Leu-enkephalin; Leucine enkephalin; Leucyl-enkephalin)
2 Cited Publications
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Based on 2 publication(s) in Google Scholar

[Leu5]-Enkephalin is a pentapeptide with morphine like properties. [Leu5]-Enkephalin is a five amino acid endogenous peptide that acts as an agonist at opioid receptors.

For research use only. We do not sell to patients.

  • Purity: 99.92%
  • CAS No.: 58822-25-6
  • Formula: C28H37N5O7
  • Molecular Weight:555.62
  • Storage:

    Sealed storage, away from moisture.

    Powder   -80°C, 2 years , -20°C, 1 year

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

  • [Leu5]-Enkephalin Chemical Structure
    [Leu5]-Enkephalin Chemical Structure
  • Experimental Validation Results for [Leu5]-Enkephalin
  • Experimental Validation Results for [Leu5]-Enkephalin
  • Experimental Validation Results for [Leu5]-Enkephalin
  • Experimental Validation Results for [Leu5]-Enkephalin
CAS No.: 58822-25-6
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Cell Proliferation/Viability AssayCell Imaging/StainingWB
  • Cell Proliferation/Viability Assay
  • Cell Proliferation/Viability Assay
  • Cell Imaging/Staining
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  • [Leu5]-Enkephalin Chemical Structure
    [Leu5]-Enkephalin Chemical Structure
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    [Leu5]-Enkephalin purchased from MedChemExpress. Usage Cited in: World J Acupunct Moxibustion. 2025 Jun 3.

    Customer Validation
     [Leu5]-Enkephalin (1-200 μM; 24 h) did not exhibit cytotoxicity in ARPE-19 cells (P > 0.05).

  • 1/16

    [Leu5]-Enkephalin purchased from MedChemExpress. Usage Cited in: World J Acupunct Moxibustion. 2025 Jun 3.

    Customer Validation
     [Leu5]-Enkephalin (10-30 µM; 24 h) significantly ameliorated the OGD-induced reduction in ARPE-19 cell viability.

  • 1/16

    [Leu5]-Enkephalin purchased from MedChemExpress. Usage Cited in: World J Acupunct Moxibustion. 2025 Jun 3.

    Customer Validation
     Impacts of naltrindole and enkephalins treatment on cell viability, morphological changes, and apoptosis rates in OGD/R-injured ARPE-19 cells (mean ± SEM, n = 4 or 5 replicates per group, scale bar = 200 µm). The results showed that following treatment with [Leu5]-Enkephalin (MEK), the cell count increased significantly, and cell morphology reverted to a normal state.

  • 1/16

    [Leu5]-Enkephalin purchased from MedChemExpress. Usage Cited in: World J Acupunct Moxibustion. 2025 Jun 3.

    Customer Validation
     Effects of naloxone and enkephalin on DOR expression in total cellular and membrane protein fractions of ARPE-19 cells under OGD/R (mean ± SEM, n = 4 independent experiments). The results showed that treatment with [Leu5]-Enkephalin (MEK) increased DOR levels in both total proteins (P <0.05) and membrane proteins (P < 0.001).

  • [Leu5]-Enkephalin