2. GPCR/G Protein
    Neuronal Signaling
    Metabolic Enzyme/Protease
  3. Neurokinin Receptor
    Endogenous Metabolite
  4. Substance P

Substance P  (Synonyms: Neurokinin P)

Cat. No.: HY-P0201 Purity: 99.37%
COA Handling Instructions

Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Substance P Chemical Structure

Substance P Chemical Structure

CAS No. : 33507-63-0

Size Price Stock Quantity
1 mg USD 66 In-stock
5 mg USD 145 In-stock
10 mg USD 264 In-stock
25 mg USD 594 In-stock
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This product is a controlled substance and not for sale in your territory.

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Based on 12 publication(s) in Google Scholar

Other Forms of Substance P:

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Description

Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).

IC50 & Target

NK1

 

Human Endogenous Metabolite

 

In Vitro

The neuropeptide substance P (SP) that are mediated by the neurokinin 1 receptor (NK1-R) desensitize and resensitize, which may be associated with NK1-R endocytosis and recycling. SP and the NK1-R are internalized into the same clathrin immunoreactive vesicles, and then sorted into different compartments. SP is intact at the cell surface and in early endosomes, but slowly degraded in perinuclear vesicles. SP induces clathrin-dependent internalization of the NK1-R. The SP/NK1-R complex dissociates in acidified endosomes. SP is degraded, whereas the NK1-R recycles to the cell surface. SP induces internalization of the NK1-R both in transfected epithelial cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

1347.63

Appearance

Solid

Formula

C63H98N18O13S
CAS No.
Sequence

Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2
Sequence Shortening

RPKPQQFFGLM-NH2
Structure Classification
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Stored under nitrogen, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (18.55 mM; Need ultrasonic)

H2O : ≥ 20 mg/mL (14.84 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.7420 mL 3.7102 mL 7.4204 mL
5 mM 0.1484 mL 0.7420 mL 1.4841 mL
10 mM 0.0742 mL 0.3710 mL 0.7420 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (1.86 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (1.86 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (1.86 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.60%

COA (242 KB) LCMS (113 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Substance P33507-63-0Neurokinin PNeurokinin ReceptorEndogenous MetaboliteNK receptorTachykinin receptorInhibitorinhibitorinhibit

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