Synthesis of a substance P antagonist with a somatostatin scaffold: factors affecting agonism/antagonism at GPCRs and the role of pseudosymmetry

  • J Med Chem. 2000 Oct 19;43(21):3827-31. doi: 10.1021/jm000316h.
J Liu  1 ,  D J Underwood ,  M A Cascieri ,  S P Rohrer ,  L D Cantin ,  G Chicchi ,  A B Smith 3rd ,  R Hirschmann
Affiliations
  • 1. Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
PMID: 11052787 DOI: 10.1021/jm000316h