α-CGRP (human)
Based on 5 publication(s) in Google Scholar
α-CGRP (human) (Calcitonin gene-related peptide) is a regulatory neuropeptide of 37 amino acids. α-CGRP (human) is widely distributed in the central and peripheral nervous system. α-CGRP (human) is a potent vasodilator and has inotropic and chronotropic effects.
For research use only. We do not sell to patients.
- Purity: 98.86%
- CAS No.: 90954-53-3
- Formula: C163H267N51O49S2
- Molecular Weight:3789.31
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) α-CGRP (human)
More
Customer Validation & Images
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WB
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Flow Cytometry
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IF
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Others
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ELISA
Biological Activity
α-CGRP (human) (3×10-11-3×10-9 moles; 45 s) can decrease the coronary perfusion pressure and increase the heart rate of isolated rat hearts, but has no significant effect on the contractility of isolated rat hearts[1].
α-CGRP (human) (3×10-11-3×10-9 moles; 45 s) can decrease the coronary perfusion pressure of isolated rabbit hearts, but has no significant effect on the heart rate and contractility of isolated rabbit hearts[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 90954-53-3
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Appearance Solid
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Molecular Weight 3789.31
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Formula C163H267N51O49S2
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Color White to off-white
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Synonyms
Calcitonin gene-related peptide
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Sequence
Ala-Cys-Asp-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2 (Disulfide bridge:Cys2-Cys7)
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Sequence Shortening
ACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF-NH2 (Disulfide bridge:Cys2-Cys7)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (5)
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Journal Impact Factor
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Most Recent
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Mater Today Bio
CGRP-empowered stem cell sheet/short nanofiber sponge via enhancing neurovascular coupling for bone regeneration. [Abstract]2026 Mar 31:38:103067. PMID: 42006713 -
Free Radic Biol Med
Oxidative stress impairs the expansion of regulatory T cells in active vitiligo via dysregulated CGRP-RAMP1-Gαi3 signaling. [Abstract]2025 Dec 24:245:18-29. PMID: 41453541
α-CGRP (human) purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Dec 24:245:18-29. [Abstract]
Representative Western blot images showing the expression levels of PCNA, phosphorylated CREB (pCREB, Ser133), total CREB, and Gαi3 proteins in MT-2 Treg-like cells transfected with control or RAMP1-specific shRNA and treated with 1 μg/mL CGRP or 50 μM H2O2 for 24 h. β-actin was used as an internal control.
α-CGRP (human) purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Dec 24:245:18-29. [Abstract]
Representative CFSE-labeled flow cytometry plots of MT-2 Tregs treated with the indicated concentrations of CGRP (0-3 μg/mL) in the absence (upper panels) or presence (lower panels) of 50 μM H2O2.
α-CGRP (human) purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Dec 24:245:18-29. [Abstract]
CGRP (5 μg/mouse/day, s.c. tail, 5 weeks). X-gal staining and immunofluorescence of tail skin sections from each group. Upper panels: X-gal staining visualizing MCs (black arrows); black dashed lines indicate borders between depigmented and normally pigmented areas. Lower panels: Immunofluorescence staining of FOXP3+ Tregs (green) with nuclei labeled by DAPI (blue); white dashed lines denote the dermal-epidermal junction, and white arrows indicate FOXP3+ Tregs.
α-CGRP (human) purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Dec 24:245:18-29. [Abstract]
CGRP (5 μg/mouse/day, s.c. tail, 5 weeks). Representative macroscopic and Wood’s lamp images of tail skin from each group.
α-CGRP (human) purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Dec 24:245:18-29. [Abstract]
CGRP (10 nM, 72 h) regulates TGF-β and IL-10 production in Tregs. Levels of TGF-β and IL-10 in Treg culture supernatants were measured by ELISA.
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Int J Pharm
Electrospun PCL/PVA core-sheath nanofibres enabling staged antibiotic and peptide delivery for diabetic foot ulcer dressings. [Abstract]2026 Jul 10:700:127062. PMID: 42252032 -
Int Immunopharmacol
Calcitonin gene-related peptide-modulated macrophage phenotypic alteration regulates angiogenesis in early bone healing. [Abstract]2024 Mar 30:130:111766. PMID: 38452411 -
Sci Rep
Transcriptomics changes of calcitonin gene-related peptide in mitigating lipopolysaccharide-induced septic cardiomyopathy. [Abstract]2024 Nov 2;14(1):26385. PMID: 39487252
Solvent & Solubility
H2O : 10 mg/mL (2.64 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (293 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.2639 mL | 1.3195 mL | 2.6390 mL | 6.5975 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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