α-CGRP (human) TFA
Based on 5 publication(s) in Google Scholar
α-CGRP (human) (TFA) is a regulatory neuropeptide of 37 amino acids. α-CGRP (human) (TFA) is widely distributed in the central and peripheral nervous system. α-CGRP (human) (TFA) is a potent vasodilator and has inotropic and chronotropic effects.
For research use only. We do not sell to patients.
- Purity: 98.12%
- Formula: C163H267N51O49S2·xC2HF3O2
- Molecular Weight:3789.31 (free base)
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* The compound is unstable in solutions, freshly prepared is recommended.
Publications Citing Use of MedChemExpress (MCE) α-CGRP (human) TFA
More-
WB
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Flow Cytometry
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IF
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Others
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ELISA
Biological Activity
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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Appearance Solid
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Molecular Weight 3789.31 (free base)
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Formula C163H267N51O49S2·xC2HF3O2
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Color White to off-white
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Synonyms
Calcitonin gene-related peptide TFA
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Sequence
Ala-Cys-Asp-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2 (Disulfide bridge:Cys2-Cys7)
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Sequence Shortening
ACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF-NH2 (Disulfide bridge:Cys2-Cys7)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * The compound is unstable in solutions, freshly prepared is recommended.
Publications (5)
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Journal Impact Factor
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Most Recent
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Mater Today Bio
CGRP-empowered stem cell sheet/short nanofiber sponge via enhancing neurovascular coupling for bone regeneration. [Abstract]2026 Mar 31:38:103067. PMID: 42006713 -
Free Radic Biol Med
Oxidative stress impairs the expansion of regulatory T cells in active vitiligo via dysregulated CGRP-RAMP1-Gαi3 signaling. [Abstract]2025 Dec 24:245:18-29. PMID: 41453541
α-CGRP (human) TFA purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Dec 24:245:18-29. [Abstract]
Representative Western blot images showing the expression levels of PCNA, phosphorylated CREB (pCREB, Ser133), total CREB, and Gαi3 proteins in MT-2 Treg-like cells transfected with control or RAMP1-specific shRNA and treated with 1 μg/mL CGRP or 50 μM H2O2 for 24 h. β-actin was used as an internal control.
α-CGRP (human) TFA purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Dec 24:245:18-29. [Abstract]
Representative CFSE-labeled flow cytometry plots of MT-2 Tregs treated with the indicated concentrations of CGRP (0-3 μg/mL) in the absence (upper panels) or presence (lower panels) of 50 μM H2O2.
α-CGRP (human) TFA purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Dec 24:245:18-29. [Abstract]
CGRP (5 μg/mouse/day, s.c. tail, 5 weeks). X-gal staining and immunofluorescence of tail skin sections from each group. Upper panels: X-gal staining visualizing MCs (black arrows); black dashed lines indicate borders between depigmented and normally pigmented areas. Lower panels: Immunofluorescence staining of FOXP3+ Tregs (green) with nuclei labeled by DAPI (blue); white dashed lines denote the dermal-epidermal junction, and white arrows indicate FOXP3+ Tregs.
α-CGRP (human) TFA purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Dec 24:245:18-29. [Abstract]
CGRP (5 μg/mouse/day, s.c. tail, 5 weeks). Representative macroscopic and Wood’s lamp images of tail skin from each group.
α-CGRP (human) TFA purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Dec 24:245:18-29. [Abstract]
CGRP (10 nM, 72 h) regulates TGF-β and IL-10 production in Tregs. Levels of TGF-β and IL-10 in Treg culture supernatants were measured by ELISA.
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Int J Pharm
Electrospun PCL/PVA core-sheath nanofibres enabling staged antibiotic and peptide delivery for diabetic foot ulcer dressings. [Abstract]2026 Jul 10:700:127062. PMID: 42252032 -
Int Immunopharmacol
Calcitonin gene-related peptide-modulated macrophage phenotypic alteration regulates angiogenesis in early bone healing. [Abstract]2024 Mar 30:130:111766. PMID: 38452411 -
Sci Rep
Transcriptomics changes of calcitonin gene-related peptide in mitigating lipopolysaccharide-induced septic cardiomyopathy. [Abstract]2024 Nov 2;14(1):26385. PMID: 39487252
Solvent & Solubility
DMSO : 25 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 25 mg/mL (Need ultrasonic)
Purity & Documentation
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Data Sheet (290 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)