2. GPCR/G Protein Neuronal Signaling
  3. CGRP Receptor
  4. α-CGRP (human) TFA

α-CGRP (human) TFA  (Synonyms: Calcitonin gene-related peptide TFA)

Cat. No.: HY-P1071A Purity: 98.12%
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α-CGRP (human) (TFA) is a regulatory neuropeptide of 37 amino acids. α-CGRP (human) (TFA) is widely distributed in the central and peripheral nervous system. α-CGRP (human) (TFA) is a potent vasodilator and has inotropic and chronotropic effects.

For research use only. We do not sell to patients.

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Based on 4 publication(s) in Google Scholar

Other Forms of α-CGRP (human) TFA:

α-CGRP (human) TFA Related Antibodies

Top Publications Citing Use of Products

    α-CGRP (human) TFA purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Dec 24:245:18-29.  [Abstract]

    Representative Western blot images showing the expression levels of PCNA, phosphorylated CREB (pCREB, Ser133), total CREB, and Gαi3 proteins in MT-2 Treg-like cells transfected with control or RAMP1-specific shRNA and treated with 1 μg/mL CGRP or 50 μM H2O2 for 24 h. β-actin was used as an internal control.

    α-CGRP (human) TFA purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Dec 24:245:18-29.  [Abstract]

    Representative CFSE-labeled flow cytometry plots of MT-2 Tregs treated with the indicated concentrations of CGRP (0-3 μg/mL) in the absence (upper panels) or presence (lower panels) of 50 μM H2O2.

    α-CGRP (human) TFA purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Dec 24:245:18-29.  [Abstract]

    CGRP (5 μg/mouse/day, s.c. tail, 5 weeks). X-gal staining and immunofluorescence of tail skin sections from each group. Upper panels: X-gal staining visualizing MCs (black arrows); black dashed lines indicate borders between depigmented and normally pigmented areas. Lower panels: Immunofluorescence staining of FOXP3+ Tregs (green) with nuclei labeled by DAPI (blue); white dashed lines denote the dermal-epidermal junction, and white arrows indicate FOXP3+ Tregs.

    α-CGRP (human) TFA purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Dec 24:245:18-29.  [Abstract]

    CGRP (5 μg/mouse/day, s.c. tail, 5 weeks). Representative macroscopic and Wood’s lamp images of tail skin from each group.

    α-CGRP (human) TFA purchased from MedChemExpress. Usage Cited in: Free Radic Biol Med. 2025 Dec 24:245:18-29.  [Abstract]

    CGRP (10 nM, 72 h) regulates TGF-β and IL-10 production in Tregs. Levels of TGF-β and IL-10 in Treg culture supernatants were measured by ELISA.

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    Description

    α-CGRP (human) (TFA) is a regulatory neuropeptide of 37 amino acids. α-CGRP (human) (TFA) is widely distributed in the central and peripheral nervous system. α-CGRP (human) (TFA) is a potent vasodilator and has inotropic and chronotropic effects[1].

    Clinical Trial
    Molecular Weight

    3789.31 (free base)

    Formula

    C163H267N51O49S2·xC2HF3O2
    Appearance

    Solid

    Color

    White to off-white

    Sequence

    Ala-Cys-Asp-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asn-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2 (Disulfide bridge:Cys2-Cys7)
    Sequence Shortening

    ACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAF-NH2 (Disulfide bridge:Cys2-Cys7)
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Sealed storage, away from moisture

    Powder -80°C 2 years
    -20°C 1 year

    *The compound is unstable in solutions, freshly prepared is recommended.

    Solvent & Solubility
    In Vitro: 

    DMSO : 25 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    H2O : 25 mg/mL (Need ultrasonic)

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    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
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    Purity & Documentation
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    α-CGRP (human) TFA Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    α-CGRP (human)Calcitonin gene-related peptideCGRP ReceptorCalcitonin gene-related peptide receptorInhibitorinhibitorinhibit

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